Thiadiazole modulators of PKB

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C546S144000

Reexamination Certificate

active

07919504

ABSTRACT:
The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein.The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

REFERENCES:
patent: 3452035 (1969-06-01), Berkelhammer et al.
patent: 3591600 (1971-07-01), Francher
patent: 3666860 (1972-05-01), Berkelhammer et al.
patent: 3740434 (1973-06-01), Berkelhammer et al.
patent: 3830924 (1974-08-01), Berkelhammer et al.
patent: 3842174 (1974-10-01), Berkelhammer et al.
patent: 3904756 (1975-09-01), Berkelhammer et al.
patent: 3932400 (1976-01-01), Hibino et al.
patent: 3991200 (1976-11-01), Berkelhammer et al.
patent: 4086238 (1978-04-01), Krenzer
patent: 4086239 (1978-04-01), Fancher
patent: 4146400 (1979-03-01), Lowski et al.
patent: 4297365 (1981-10-01), Rajappa et al.
patent: 4451471 (1984-05-01), Ferrini et al.
patent: 4496560 (1985-01-01), Farge et al.
patent: 4596802 (1986-06-01), Wermuth et al.
patent: 4851418 (1989-07-01), Sanchez
patent: 4886833 (1989-12-01), Gayer et al.
patent: 5057520 (1991-10-01), Chu et al.
patent: 5086053 (1992-02-01), Brodin et al.
patent: 5145860 (1992-09-01), Takasugi et al.
patent: 5232921 (1993-08-01), Biziere et al.
patent: 5254685 (1993-10-01), Yokomoto et al.
patent: 5290794 (1994-03-01), Mehta et al.
patent: 5302608 (1994-04-01), Sohda et al.
patent: 5410024 (1995-04-01), Pettit et al.
patent: 5550138 (1996-08-01), Sohda et al.
patent: 5693643 (1997-12-01), Gilbert et al.
patent: 5834401 (1998-11-01), Kawamura et al.
patent: 5856347 (1999-01-01), Hashiguchi et al.
patent: 5977027 (1999-11-01), Kawamura et al.
patent: 6323315 (2001-11-01), Pettit et al.
patent: 6420400 (2002-07-01), Zhang et al.
patent: 6521643 (2003-02-01), Tomishima et al.
patent: 6525052 (2003-02-01), Bekkali et al.
patent: 6620911 (2003-09-01), Pettit et al.
patent: 6720427 (2004-04-01), Sanner et al.
patent: 6894054 (2005-05-01), Laborde et al.
patent: 6962933 (2005-11-01), Ohkawa et al.
patent: 6982272 (2006-01-01), Emmanuel et al.
patent: 2001/0044545 (2001-11-01), Dhanca et al.
patent: 2002/0025976 (2002-02-01), Chu et al.
patent: 2002/0115863 (2002-08-01), Patel et al.
patent: 2002/0119962 (2002-08-01), Jacobs et al.
patent: 2003/0078252 (2003-04-01), Sanner et al.
patent: 2003/0216403 (2003-11-01), Lively et al.
patent: 2004/0053948 (2004-03-01), McDonald et al.
patent: 2004/0053973 (2004-03-01), Ohkawa et al.
patent: 2004/0097555 (2004-05-01), Ohkawa et al.
patent: 2004/0102360 (2004-05-01), Barnett et al.
patent: 2004/0106540 (2004-06-01), Barnett et al.
patent: 2004/0116439 (2004-06-01), Lively et al.
patent: 2004/0122016 (2004-06-01), Cao et al.
patent: 2004/0152747 (2004-08-01), Chen et al.
patent: 2004/0157827 (2004-08-01), Pevarello et al.
patent: 2004/0171643 (2004-09-01), De Cointet et al.
patent: 2005/0004134 (2005-01-01), Tsutsumi et al.
patent: 2005/0038059 (2005-02-01), Mueller et al.
patent: 2005/0043372 (2005-02-01), Chen
patent: 2005/0053594 (2005-03-01), Alessi et al.
patent: 2005/0080113 (2005-04-01), Ohkawa et al.
patent: 2005/0119320 (2005-06-01), Bruce et al.
patent: 2005/0143384 (2005-06-01), Sartori et al.
patent: 2005/0148640 (2005-07-01), Come et al.
patent: 2005/0176789 (2005-08-01), Hadida Ruah et al.
patent: 2005/0182104 (2005-08-01), Balter et al.
patent: 2005/0192300 (2005-09-01), Wang et al.
patent: 2005/0222219 (2005-10-01), Chen et al.
patent: 2005/0256121 (2005-11-01), Jefferson et al.
patent: 2006/0003944 (2006-01-01), Glinka et al.
patent: 2006/0052426 (2006-03-01), Despeyroux et al.
patent: 2006/0154961 (2006-07-01), Zeng et al.
patent: 2006/0178388 (2006-08-01), Wrobleski et al.
patent: 2006/0205731 (2006-09-01), Kodama et al.
patent: 2006/0287317 (2006-12-01), Smith et al.
patent: 2006/0293365 (2006-12-01), Baltzer et al.
patent: 2006/0293366 (2006-12-01), Baltzer et al.
patent: 2007/0032487 (2007-02-01), Bruce et al.
patent: 2007/0173506 (2007-07-01), Zeng et al.
patent: 2008/0255145 (2008-10-01), Monenschein et al.
patent: 2008/0269243 (2008-10-01), Monenschein et al.
patent: 2009/0099221 (2009-04-01), Vanotti et al.
patent: 2009/0203690 (2009-08-01), Akritopoulou-Zanze et al.
patent: 1045136 (1978-12-01), None
patent: 3407505 (1985-09-01), None
patent: 2022085 (1979-12-01), None
patent: 64-75475 (1989-03-01), None
patent: 5117280 (1993-05-01), None
patent: 8073460 (1996-03-01), None
patent: 9221424 (1997-08-01), None
patent: 2002-53565 (2002-02-01), None
patent: 20020-53566 (2002-02-01), None
patent: WO 93/19054 (1993-09-01), None
patent: WO 96/38419 (1996-12-01), None
patent: WO 97/22360 (1997-06-01), None
patent: WO 99/31096 (1999-06-01), None
patent: WO 99/65884 (1999-12-01), None
patent: WO 00/45635 (2000-08-01), None
patent: WO 01/44178 (2001-06-01), None
patent: WO 01/44179 (2001-06-01), None
patent: WO 01/87877 (2001-11-01), None
patent: WO 03/014095 (2003-02-01), None
patent: WO 03/068227 (2003-08-01), None
patent: WO 02/083064 (2003-10-01), None
patent: WO 03/084473 (2003-10-01), None
patent: WO 03/094831 (2003-11-01), None
patent: WO 2004/014864 (2004-02-01), None
patent: WO 2004/041813 (2004-05-01), None
patent: WO 2004/046120 (2004-06-01), None
patent: WO 2004/056789 (2004-07-01), None
patent: WO 2004/089937 (2004-10-01), None
patent: WO 2004/096131 (2004-11-01), None
patent: WO 2005/014554 (2005-02-01), None
patent: WO 2005/046678 (2005-05-01), None
patent: WO 2005/052147 (2005-06-01), None
patent: WO 2005/068444 (2005-07-01), None
patent: WO 2005/089443 (2005-09-01), None
patent: WO 2005/113762 (2005-12-01), None
patent: WO 2005/116025 (2005-12-01), None
patent: WO 2006/020767 (2006-02-01), None
patent: WO 2006/038734 (2006-04-01), None
patent: WO 2006/044860 (2006-04-01), None
patent: WO 2006/045716 (2006-05-01), None
patent: WO 2006/051270 (2006-05-01), None
patent: WO 2007/008541 (2007-01-01), None
patent: WO 2007/033780 (2007-03-01), None
patent: WO 2007/066805 (2007-06-01), None
patent: WO 2007/070600 (2007-06-01), None
patent: WO 2007/084391 (2007-07-01), None
patent: WO 2007/110344 (2007-10-01), None
patent: WO 2008/036308 (2008-03-01), None
patent: WO 2008/154241 (2008-12-01), None
patent: WO 2009/133170 (2009-11-01), None
Aoyama, T. et al., “One Pot Synthesis using Supported Reagents System KSCN/SiO2—RNH3OAc/A12O3:synthesis of 2-aminothiazoles and N-Allylthioureas,” Tetrahedron, 62(14), 3201-3213 (2006).
Arevalo, M. J. et al., “Expeditious Formation of 1,2,4-Triazine Derivatives via a Thioisomunchnone Cycloaddition Reaction,” Tet. Lett., 40, 8675-8678 (1999).
Bellacosa, A. et al., “Molecular Alterations of the AKT2 Oncogene in Ovarian and Breast Carcinomas,” Int. J. Cancer (Pred. Oncol.), 64, 280-285 (1995).
Besson, A. et al., “PTEN/MMAC1/TEP1 in Signal Transduction and Tumorigenesis,” Eur. J. Biochem., 263, 605-611 (1999).
Beyer, H. et al., “Folgeprodukte der Thiazolyl-(2)-cyanamide,” Chem. Ber., 99(9), 2937-2943 (1966). This in in German. English language abstract is attached.
Blume-Jensen, P. et al., “OncogenicKinase Signalling,” Nature, 411, 355-365 (2001).
Brazil, D. P. et al., “Ten Years of Protein Kinase B Signalling: a hard Akt to follow,” Trends Biochem Sci., 11, 657-664 (2001).
Brodbeck, D. et al., “A Human Protein Kinase Bγ with Regulatory Phosphorylation Sites in the Activation Loop and in the C-terminal Hydrophobic Domain,” J. Biol. Chem., 274, 9133-9136 (1999).
Cheng, J. Q. et al., “AKT2, a Putative Oncogene Encoding a Member of a Subfamily of Protein-Serine/Threonine Kinases, is Amplified in Human Ovarian Carcinomas”, PNAS, 89, 9267-9271 (1992).
Cheng, J. Q. et al.,“Amplification of AKT2 in Human Pancreatic Cancer Cells and Inhibition of AKT2 Expression and Tumorigenicity by Antisense RNA”, PNAS, 93, 3636-3641 (1996).
Czech, M. P. et al., “Signaling Mechanisms that Regu

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Thiadiazole modulators of PKB does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thiadiazole modulators of PKB, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thiadiazole modulators of PKB will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2634141

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.