Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-04-10
1998-12-08
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
514363, 548491, 548579, 546334, 544358, 544360, 544106, 544 60, 549436, C07D285125, C07D20908, C07D24104, A01N 4382
Patent
active
058471480
ABSTRACT:
The present invention provides novel thiadiazole derivatives represented by formula I: ##STR1## or pharmaceutical acceptable salts thereof wherein the compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, predominantly stromelysins, and hence are useful for the treatment of matrix metallo endoproteinase diseases such as osteoarthritis, rheumatoid arthritis, septic arthritis, osteopenias such as osteoporosis, tumor metastasis (invasion and growth), periodontitis, gingivitis, corneal ulceration, dermal ulceration, gastric ulceration, and other diseases related to connective tissue degradation.
Harper Donald E.
Jacobsen Eric J.
Mitchell Mark A.
Schostarez Heinrich J.
Keating Dominic
Pharmacia & Upjohn Company
Richter Johann
Yang Lucy X.
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