Thiadiazole derivatives for the treatment of depressive states

Details Thiadiazole derivatives for the treatment of depressive states Thiadiazole derivatives for the treatment of depressive states

1993-07-09

1995-03-28

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548139, 548141, A01K 3141

Patent

active

054018536

ABSTRACT:
Thiadiazole derivatives of general formula (I) ##STR1## wherein R.sub.1 is selected from the class consisting of: C.sub.1 -C.sub.10 linear or branched alkyl, benzyl, optionally substituted at the aromatic ring with one or more groups selected on their turn from the class consisting of : C.sub.1 -C.sub.20 linear or branched alkyl residues , nitro groups, halogen atoms, C.sub.1 -C.sub.20 linear or branched alkoxy, hydroxy and C.sub.2 -C.sub.20 linear or branched acyloxy groups, R.sub.2 is selected from H, C.sub.2 -C.sub.10 alkanoyl, cycloalkanoyl wherein this ring has from 3 to 10 carbon atoms, aroyl, and R.sub.3 is selected from H and C.sub.1 -C.sub.10 alkyl, for the treatment of depressive states and anxiety, a process for their preparation and relative pharmaceutical compositions containing them as the active ingredient.

REFERENCES:
patent: 3903099 (1975-09-01), Rathgeb
patent: 4639526 (1987-01-01), Metzger
Dornow, Chem. Ber. 99, 72(1966).
Pharmaceutical Basis of Therapeutics, Goodman et al., Ital. Ed of 6th Amer. Ed., pp. 440-456 (1978).

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