Thiadiazole compounds useful as inhibitors of H.sup.+ /K.sup.+

Details Thiadiazole compounds useful as inhibitors of H.sup.+ /K.sup.+ Thiadiazole compounds useful as inhibitors of H.sup.+ /K.sup.+

1998-04-06

2000-05-09

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544357, 544364, 544367, A61K 31496, C07D41704, C07D41714

Patent

active

060604727

ABSTRACT:
Novel 3,5-disubstituted 1,2,4-thiadiazole compounds are provided, which are effective in treating peptic ulcers by the inhibition of H.sup.+ /K.sup.+ -ATPase. The compounds of the present invention are 3,5-disubstituted 1,2,4-thiadiazole corresponding to the general formula (I): ##STR1## where R.sup.1 is a group with cell penetration properties for the inhibition of the enzyme in-vitro and in-vivo, and Y is a substituent that tunes the reactivity of the inhibitor towards the cysteine residue of H.sup.+ /K.sup.+ -ATPase. The Y group may also serve in recognition.

REFERENCES:
patent: 4613601 (1986-09-01), Regnier et al.

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