Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1997-06-18
1998-11-03
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514363, 514414, 514415, 514422, 514423, 514563, 514613, 514616, 548139, 548141, 548491, 548523, 564139, 564152, 564155, 564342, 564372, A61K 31425, C07C 49297, C07C23714, C07D285125
Patent
active
058308695
ABSTRACT:
The present invention provides novel thiadiazole amide derivatives represented by formula I ##STR1## The compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, predominantly stromelysins, and hence are useful for the treatment of matrix metallo endoproteinase diseases such as osteoarthritis, rheumatoid arthritis, septic arthritis, osteopenias such as osteoporosis, tumor metastasis, periodontitis, gingivitis, corneal ulceration, dermal ulceration, gastric ulceration, inflammation and other diseases related to connective tissue degradation.
REFERENCES:
patent: 5712300 (1998-01-01), Jacobsen
Lindberg Thomas J.
Maggiora Linda Louise
Mitchell Mark Allen
Schostarez Heinrich Josef
Oswecki Jane C.
Richter Johann
Yang Lucy X.
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