Thiabicycloheptane substituted prostaglandin analogs useful in t

Details Thiabicycloheptane substituted prostaglandin analogs useful in t Thiabicycloheptane substituted prostaglandin analogs useful in t

1985-02-20

1986-05-13

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 49, 549 53, 549 58, A61K 3138, C07D33350

Patent

active

045887420

ABSTRACT:
Thiabicycloheptane substituted prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.

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"New Synthetic Approaches to Symmetrical Sulfur-Bridged Carbocycles" by Corey, et al., The Journal of Org. Chem., vol. 31, No. 6, pp. 1663-1668.
"Thiosteroids-XXVII.sup.1 Steroidal Transannular 2.alpha.,5.alpha.-Episulphide-I., Synthesis of 5.alpha.-Cholestan-2.alpha.,5-Episulphide Derivatives" by Komeno et al., Tetrahedron, vol. 27, pp. 1503-1516.

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