Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2006-12-12
2006-12-12
Martinell, James (Department: 1634)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C435S196000
Reexamination Certificate
active
07148049
ABSTRACT:
The present invention provides thermostable or thermoactive DNA polymerases with attenuated 3′-5′ exonuclease activity, methods for their synthesis, methods for their use, kits comprising the polymerases, nucleic acids encoding the polymerases and cells comprising such a nucleic acid. The DNA polymerases of the invention are useful in many recombinant DNA techniques, such as nucleic acid amplification by the polymerase chain reaction. The DNA polymerases of the invention allow higher fidelity replication and amplification of a template DNA sequence, allow less degradation of primers and/or more efficient use of deoxynucleotide triphosphates and are in general more efficient and less costly to make and use.
REFERENCES:
patent: 5420029 (1995-05-01), Gelfand et al.
patent: 5948614 (1999-09-01), Chatterjee
patent: 6218150 (2001-04-01), Uemori et al.
patent: 6228628 (2001-05-01), Gelfand et al.
American Type Culture Collection webpage (http://www.atcc.org/common/catalog/wordSearch/results.cfm).
Gelfand David H.
Myers Thomas W.
Schoenbrunner Nancy J.
Martinell James
Roche Molecular Systems Inc.
Sappenfield Christopher
Townsend and Townsend / and Crew LLP
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