Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-04-18
2006-04-18
Horlick, Kenneth R. (Department: 1637)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S006120, C435S091100, C435S091200, C536S023100, C536S024300, C536S024330
Reexamination Certificate
active
07030220
ABSTRACT:
A purified thermostable enzyme is derived from the thermophilic archaebacteriumArchaeoglobus fulgidus. The enzyme can be native or recombinant, is stable under PCR conditions and exhibits double strand specific exonuclease activity. It is a 3′–5′ exonuclease and cleaves to produce 5′-mononucleotides. Thermostable exonucleases are useful in many recombinant DNA techniques, in combination with a thermostable DNA polymerase like Tag especially for nucleic acid amplification by the polymerase chain reaction (PCR).
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Ankenbauer Waltraud
Greif Michael
Laue Frank
Sobek Harald
Horlick Kenneth R.
Kim Young J.
Roche Diagnostics GmbH
Roche Molecular Systems Inc.
Townsend & Townsend & Crew LLC
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