Thermosensitive poly (organophosphazenes), preparation...

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – From carboxylic acid or derivative thereof

Reexamination Certificate

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C524S725000, C524S726000, C524S755000, C524S765000, C524S770000, C525S054100, C525S538000, C525S540000, C528S332000, C528S399000, C528S400000, C528S422000

Reexamination Certificate

active

10835378

ABSTRACT:
Disclosed are polyphosphazenes of Formula 1 showing a sol-gel behavior with a temperature change, a preparation method thereof, and injectable thermosensitive polyphosphazene hydrogels using the same

REFERENCES:
patent: 6319984 (2001-11-01), Song et al.
patent: 2002/0014616 (2002-02-01), Allcock et al.
patent: 1020000002785 (2000-01-01), None
patent: 1020010047025 (2001-06-01), None
Jeong, Byeongmoon, et al., “Thermosensitive sol-gel reversible hydrogels”, Advanced Drug Delivery Reviews, 2002, vol. 54, pp. 37-51.
Hatefi, A., et al., “Biodegradable injectable in situ forming drug delivery systems”, Journal of Controlled Release, 2002, vol. 80, pp. 9-28.
Jeong, B., et al., “New biodegradable polymers for injectable drug delivery systems”, Journal of Controlled Release, 1999, vol. 62, pp. 109-114.
Song, Soo-Chang, et al., “A New Class of Biodegradable Thermosensitive Polymers. I. Synthesis and Characterization of Poly(organophosphazenes) with Methoxy-Poly (ethylene glycol) and Amino Acid Esters as Side Groups”, Macromolecules, 1999, vol. 32, pp. 2188-2193.
Lee, Sang Beom, et al., “A New Class of Biodegradable Thermosensitive Polymers. 2. Hydrolytic Properties and Salt Effect on the Lower Critical Solution Temperature of Poly(organophosphazenes) with Methoxylpoly(ethylene glycol) and Amino Acid Esters as Side Groups”, Macromolecules, 1999, vol. 32, pp. 7820-7827.
Lee, Bae Hoon, et al., “A Thermosensitive Poly(organophosphazene) Gel”, Macromolecules, 2002, vol. 35, pp. 3876-3879.

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