Thermosensitive liposome and process for preparing the same

Details Thermosensitive liposome and process for preparing the same Thermosensitive liposome and process for preparing the same

1997-01-14

1998-02-24

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 264 43, 264 433, A61K 9127

Patent

active

057209766

ABSTRACT:
The present invention provides a thermosensitive liposome which permits temperature-sensitive drug release and exhibits variable release temperatures. The process for preparing a thermosensitive liposome of the invention, comprises a step of coating the surface of a liposome with a copolymer of N-isopropylacrylamide/octadecylacrylate/acrylic acid, by the addition of the copolymer to the liposome suspension in a weight ratio of 1:0.05 to 1:0.2 (liposome:copolymer), and the incubation of the polymer-liposome suspension at a temperature range of 0.degree. to 10.degree. C., for 10 to 14 hours. The thermosensitive liposome of the present invention is able to control the temperature of drug release at a temperature range of above 28.degree. C., preferably at 28.degree. to 36.degree. C., depending on the acrylic acid content in the copolymer of N-isopropylacrylamide/octadecylacrylate/acrylic acid.

REFERENCES:
patent: 4804539 (1989-02-01), Guo
patent: 5008109 (1991-04-01), Tin
T. Tomita et al., "Temperature-Sensitive Release of Adriamycin, an Amphiphilic Antitumor Agent, from Dipalmitoylphosphatidylcholine-Cholesterol Liposomes", Biochim. Biophys. Acta, 978:185-190(1989).
N. Oku et al., "Potential Usage of Thermosensitive Liposomes for Macromolecule Delivery", Biochim. Biophys. Acta, 1191: 389391(1994).
K. Kono et al., "Temperature-Sensitive Liposomes: Liposomes Bearing poly (N-isopropylacrylamide)", Journal of Controlled Release, 30:69-75(1994).
K. Maruyama et al., "Enhanced Delivery of Doxorubicin to Tumor by Long-Circulating Thermosensitive Liposomes and Local Hyperthermia", Biochim. Biophys. Acta, 1149:209-216(1993).
J. N. Weinstein et al., "Phase Transition Release, a New Approach to The Interaction of Proteins with Lipid Vesicles", Biochim. Biophys. Acta, 647:270-284(1981).

Affiliated with

Also associated with

Rating

Thermosensitive liposome and process for preparing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thermosensitive liposome and process for preparing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thermosensitive liposome and process for preparing the same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1873710