Thermosensitive and biocompatible amphiphilic...

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...

Reexamination Certificate

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C525S054110, C525S419000, C525S420000, C525S538000

Reexamination Certificate

active

07598318

ABSTRACT:
The present invention relates to a thermosensitive and biocompatible poly(organophosphazenes) represented by Formula 1, and a preparation method thereof:wherein R is a methyl or ethyl group; R′ is selected from the group consisting of COOR, CH2COOR, CH2CH2COOR, CH2CH(CH3)2, CH2C6H5, CH(CH3)CH2CH3and CH3; R″ is selected from the group consisting of CH2COOR, CH2CH2COOR, CH2CH(CH3)2, CH2C6H5, CH(CH3)CH2CH3and CH3; R′″ is a group selected from the group consisting of CH2COOR, CH2CH2COOR and H, wherein R is the same as defined above; n is a number between from 30 to 100; x is a number selected from the integers of 3, 4, 7, 12 and 16; y is a number between from 0.5 to 1.5; a equals to 1; and b and c equal to 0 or 1.

REFERENCES:
Song, Soo-Chang et al. (1999). “A New Class of Biodegradable Thermosensitive Poymers. I. Synthesis and Characterization of Poly(organophosphazenes) with Methoxy-Poly(ethylene glycol) and Amino Acid Esters as Side Groups,”Macromolecules32(7): 2188-2193.
Lee, Bae Hoon et al. (2002). “A Thermosensitive Poly(organophosphazene) Gel,”Macromolecules35(10): 3876-3879.
Lee, Bae Hoon et al. (2002). “Thermosensitive and Hydrolysis-sensitive Poly(organophosphazenes),”Polymer International51: 658-660.
Lee, Bae Hoon et al. (2002). “Synthesis and Characterization of Thermosensitive Poly(organophosphazenes) with Methoxy-Poly(ethylene glycol) and Alkylamines as Side Groups,”Bulletin of the Korean Chemical Society23(4): 549-554.
Kim, Joo Ik et al. (2004). “Synthesis and Characterization of Nanosized Poly(organophosphazenes)with Methoxy-poly(ethylene glycol) and Dipeptide Ethyl Esters As Side Groups,”Polymer45: 7083-7089.
Seong, Ji-Yeon et al. (2005). “New Thermogelling Poly(organophosphazenes)with Methoxypoly(ethylene glycol) and Oligopeptide As Side Groups,”Polymer46: 5075-5081.

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