Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1998-05-13
2000-09-19
Harrison, Robert H.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424404, 424405, 424409, 424412, 514495, 514953, A61K 3338, C08L 7100, A01N 2510
Patent
active
06120790&
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to thermoplastic resin compositions, and more specifically to resin compositions compounded with an antimicrobial/fungistatic agent. The purpose thereof is to offer antimicrobial/fungistatic resin compositions with good dispersion when used as moulded products or as resin improving agents.
2. Description of the Prior Art
Prior compositions are known for conferring antimicrobial/fungistatic properties on resins. There are a variety of antimicrobial/fungistatic agents, including natural products, organic compounds and inorganic compounds; however, in the main, natural products have a low boiling point and are difficult to handle. Organic compounds show good phase solubility with resins, but are not very heat stable, and there is the problem of a lowering of performance due to decomposition in the process of melting, etc. Inorganic compounds on the other hand are exceedingly stable but have the problem of lowered performance due to poor dispersion in resins and elution by water.
The present invention is intended to offer compositions in which these antimicrobial/antifungal agents disperse well in the resin, are stable and are not eluted to any extent, and have an outstandingly persistent effect; and we have discovered that this purpose can be achieved by compounding with specified resins.
SUMMARY OF THE INVENTION
The present invention is a thermoplastic resin composition characterized in that an antimicrobial/fungistatic agent is compounded at 0.05-20 wt % with a polymer containing a polyether chain as a constituent unit.
The "antimicrobial/fungistatic agent" in the present invention includes natural products (cypress thiol, chitin, chitosan, etc.), organic compounds (imidazoles, thiazoles, nitrites, haloalkylthio compounds, pyridines, thiazines, bromine compounds, quaternary ammonium compounds, etc.) and inorganic compounds (zeolites, zirconium phosphate, calcium phosphate, titania and silica, etc.); however, inorganic compounds including silver ions are particularly preferred.
The "polymer containing a polyether chain as a constituent unit" in the present invention is a block copolymer in which a polyoxyalkylene chain is connected to another macromolecular chain, or a polymer in which polyoxyalkylene chains are linked via linking portions. Examples of polyoxyalkylenes here include polyoxyethylene, poly(1,2- and 1,3-oxypropylene), polyoxytetramethylene, polyoxyhexamethylene, block and random copolymers of ethylene oxide and propylene oxide, and block and random copolymers of ethylene oxide and tetrahydrofuran, etc. The alkylene portion particularly preferably has 2-4 carbons, and polyoxyethylene and polyoxytetramethylene are most preferred.
The number average molecular weight of the polyoxyalkylene is preferably in the range 300-6000, and more preferably 500-4000.
Within the present invention polyether/polyamide block copolymers, polyether/polyester block copolymers and polyether urethanes are preferably used as the "polymer containing a polyether chain as a constituent unit".
Within the present invention a "polyether/polyamide block copolymer" is a copolymer in which a poly(alkylene oxide) chain (a) is linked with a polyamide chain (b) which is a polymer of an aminocarboxylic acid or a lactam of 6 carbons or a salt of a dicarboxylic acid and a diamine of 6 carbons. Copolymers in which (a) and (b) are linked via a dicarboxylic acid of 4-20 carbons are termed generally polyether ester amides. These polymers can be made, for example, by the method of Japanese Examined Patent 56-45419. Concrete examples include Pebax (Elf-Atochem), Ely (Ems) and Vestamide (Huls). The types and proportions of the polyamide component and polyether component in block copolymers used in the present invention can be selected according to the purpose and end use.
As aminocarboxylic acids or lactams of 6 carbons or salts of a dicarboxylic acid and a diamine of 6 carbons here, 11-aminoundecanoic acid, 12-aminododecanoic acid, caprolactam, laurolacta
REFERENCES:
patent: 4739012 (1988-04-01), Hagman
patent: 5607683 (1997-03-01), Capelli
patent: 5820918 (1998-10-01), Ronan et al.
Terui, Chemical Abstracts, vol. 117, #9236, 1992.
Kuratsuji Takatoshi
Maillet Jerome
Miyaki Yoshiyuki
Elf Atochem S.A.
Harrison Robert H.
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