Thermophilic fungal expression system

Details Thermophilic fungal expression system Thermophilic fungal expression system

1995-06-01

1997-02-18

Ketter, James S.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Fungi

435911, C12N 115

Patent

active

056041292

ABSTRACT:
The present invention relates to recombinant thermophilic host cells comprising a nucleic acid sequence encoding a heterologous protein, and a method of producing recombinant protein utilizing same. The recombinant hosts of the present invention provide a better morphology in tank fermentations than many known fungal host cells, such as Aspergillus, which morphology results in lower viscosity levels, and therefore improved productivity.

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Jain et al., MGG, vol. 234, No. 3, pp. 489-493, 1992.
Allison et al., Current Genetics, vol. 21, No. 3, pp. 225-229, 1992.
Christensen et al., Biotechnology, vol. 6, pp. 1419-1422, 1988.
Drocourt et al., Nucleic Acids Research, vol. 18, No. 13, 1990.
Onions et al., Smith's Introduction to Industrial Mycology, 7th ed., 1981, John Wiley & Sons, New York, pp. 142-144.

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