Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1990-04-10
1991-11-26
Bond, Robert T.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
C07D49816, A61K 31395
Patent
active
050683233
ABSTRACT:
Ring-expanded macrolides related to FK-506 have immunosuppressive activity.
REFERENCES:
"Protective Groups in Organic Syntheses" by Theodora W. Greene, Chapter Title pages for: Protection for the Hydroxyl Group Including 1,2-and 1,3-Diols.
J. Am. Chem. Soc., vol. 109 (1987), pp. 5031-5033, describes FK-506 and its properties.
Arison Byron H.
Beattie Thomas R.
Fisher Michael H.
Ok Hyun
Wyvratt, Jr. Matthew J.
Bond Robert T.
Caruso Charles M.
Harbour John W.
Merck & Co. , Inc.
North Robert J.
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