Thermally assisted membrane introduction mass spectrometry...

Details Thermally assisted membrane introduction mass spectrometry... Thermally assisted membrane introduction mass spectrometry...

2007-01-09

2009-08-25

Berman, Jack I (Department: 2881)

Radiant energy

Ionic separation or analysis

With sample supply means

C250S281000, C250S282000

Reexamination Certificate

active

07579587

ABSTRACT:
A membrane introduction mass spectrometry (MIMS) sampling interface is presented that demonstrates improved online performance for the direct, real-time measurement of semi-volatile organic compounds (SVOCs) in samples such as air and water, at parts-per-billion and parts-per-trillion levels. The device is based upon a capillary hollow fiber silicone (polydimethylsiloxane) membrane in a ‘flow-over’ configuration that is resistively heated on the membrane interior. One embodiment resistively heats using a coaxial nichrome wire, establishing a thermal gradient counter to the analyte concentration gradient. This arrangement allows for continuous and/or pulsed heating modes, affording excellent sensitivity for the online measurement of SVOCs while retaining sensitivity for volatile organic compounds (VOCs). In addition, the signal response time for SVOCs is reduced substantially over conventional MIMS methods. Separation and quantitation of analytes is achieved using quadrupole ion trap tandem mass spectrometry or selected ion monitoring mass spectrometry.

REFERENCES:
patent: 5448062 (1995-09-01), Cooks et al.
patent: 5517026 (1996-05-01), Sickenberger et al.

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