Thermal microvalves in a fluid flow method

Details Thermal microvalves in a fluid flow method Thermal microvalves in a fluid flow method

1997-07-03

2000-04-11

Ludlow, Jan

Chemistry: analytical and immunological testing

Including sample preparation

Volumetric liquid transfer

422100, 422103, G01N 110, G01N 138

Patent

active

060487348

ABSTRACT:
The movement and mixing of microdroplets through microchannels is described employing silicon-based microscale devices, including microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. The discrete droplets are differentially heated and propelled through etched channels. Electronic components are fabricated on the same substrate material, allowing sensors and controlling circuitry to be incorporated in the same device.

REFERENCES:
patent: 4439526 (1984-03-01), Columbus
patent: 4457329 (1984-07-01), Werley et al.
patent: 4522786 (1985-06-01), Ebersole
patent: 4599315 (1986-07-01), Terasaki et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis et al.
patent: 4919892 (1990-04-01), Plumb
patent: 4963498 (1990-10-01), Hillman et al.
patent: 4967950 (1990-11-01), Legg
patent: 5048554 (1991-09-01), Kremer
patent: 5091328 (1992-02-01), Miller
patent: 5160945 (1992-11-01), Drake
patent: 5192507 (1993-03-01), Taylor et al.
patent: 5223226 (1993-06-01), Wittmer et al.
patent: 5252743 (1993-10-01), Barrett et al.
patent: 5275787 (1994-01-01), Yuguchi et al.
patent: 5304487 (1994-04-01), Wilding et al.
patent: 5364591 (1994-11-01), Green et al.
patent: 5416000 (1995-05-01), Allen et al.
patent: 5474796 (1995-12-01), Brennan
patent: 5494639 (1996-02-01), Grzegorzewski
patent: 5498392 (1996-03-01), Wilding et al.
patent: 5533412 (1996-07-01), Jerman et al.
patent: 5585069 (1996-12-01), Zanzucchi et al.
patent: 5587128 (1996-12-01), Wilding et al.
patent: 5651839 (1997-07-01), Rauf
patent: 5700637 (1997-12-01), Southern
Marmur and Lane, "Strand Separation and Specific Recombination in Deoxyribonucleic Acids: Biological Studies", Proc.Nat.Acad.Sci., U.S.A. 46:453-461 (1960).
Doty et al., "Strand Separation and Specific Recombination in Deoxyribonucleic Acids: Physical Chemical Studies", Proc.Nat.Acad.Sci., U.S.A. 46:461-477 (1960).
Hayashi et al., "Restriction of in Vivo Genetic Transcription to one of the Complementary Strands of DNA", Proc.Nat.Acad.Sci., U.S.A. 50: 664-671 (1963).
Smith and Wilcox, "A Restriction Enzyme from Hemophilus influenzae", J.Mol.Biol. 51:379-391 (1970).
Southern, "Detection of Specific Sequences Among DNA Fragments Separated by Gel Electrophoresis", J.Mol.Biol. 98:503-517 (1975).
Maxam and Gilbert, "A new method for sequencing DNA", Proc. Natl. Acad Sci. USA 74:560-564(1977).
Sanger et al., "DNA sequencing with chain-terminating inhibitors", Proc. Natl. Acad Sci. USA 74:5463-5467 (1977).
Chen and Seeburg, "Laboratory Methods Supercoil Sequencing: A Fast and Simple Method for Seqencing Plasmid DNA", DNA 4(2):165-170 (1985).
Graham et al., "Direct DNA sequencing using avian myeloblastosis virus and Moleney murine leukemia virus reverse transcriptase", Bethesda Res. Lab. Focus 8(2):;4 (1986).
Sambrook, J. et al., Molecular Cloning, A Laboratory Manual, 2d Ed. Cold Spring Harbor Laboratory Press, New York, 13.7-13.9.
Hunkapiller, M.W., "Advances in DNA sequencing technology", Curr. Op. Gen. Devl. 1:88-92 (1991).
Tabor et al., "DNA sequence analysis with a modified bacteriophage T7 DNA polymerase", Proc. Natl. Acad. Sci. USA 84:4767-4771 (1987).
Innis et al., "DNA sequencing with Thermus aquaticus DNA polymerase and direct sequencing of polymerase chain reaction-amplified DNA", Proc. Natl. Acad. Sci. USA 85:9436-9440 (1988).
J. Pfahler et al., "Liquid Transport in Micron and Submicron Channels", Sensors and Actuators A21-A23: 431-434 (1990).
H.T.G. Van Lintel et al., "A Piezoelectric Micropump Based on Micromachining of Silicon", Sensors and Actuators 15:153-167 (1988).
Smits, "Piezoelectric Micropump with Three Valves Working Peristaltically," Sensors and Actators A21-A23:203-206 (1990).
Mullis and Faloona, "Specific Synthesis of DNA in Vitro via a Polymerase-Catalyzed Chain Reaction," Meth. Enzym. 155:335-350 (1987).
Arnheim, "Polymerase Chain Reaction Strategy," Annu. Rev. Biochem. 61:131-156 (1992).
Nickerson et al., "Automated DNA diagnostics using an ELISA-based oligonucleotide ligation assay," Proc. Nat. Acad. Sci. USA 87:8923-8927 (1990).
Gordon et al., "Capillary Electrophoresis," Science 27:224-228 (1988).
Lawrence Berkely Lab Presentation, Park City, Utah (1993).
Turner, "New Dimensions in Capillary Electrophoresis Columns," LC-GC vol. 9 (1991).
Heller and Tullis, "Microelectrophoresis for the separation of DNA fragments," Electrophoresis 13:512-520 (1992).
Manz et al., "Planar chips technology for miniaturization and integration of separation techniques into monitoring systems Capillary electrophoresis on a chip," J. Chrom. 593:253-258 (1992).
Jorgenson and Lukacs, "High-Resolution Separations Based on Electrophoresis and Electroosmosis," J. Chrom. 218:209-216 (1981).
Chamberlain et al., "BRCA1 Maps Proximal to D17S579 on Chromosome 17q21 by Genetic Analysis," Am. J. Hum. Genet. 52:792-798 (1993).
Ansorge et al., "High-throughput automated DNA sequencing facility with fluorescent labels at the European Molecular Biology Laboratory," Electrophoresis 13:616-619 (1992).
Pentoney et al., "A single-fluor approach to DNA sequence determination using high performance capillary electrophoresis," Electrophoresis 13:467-474 (1992).
Tenan et al., "Friction in Capillary Systems," Journal of Applied Physics 53:6687-6692 (1982).
Dussan, "On the Spreading of Liquids on Solid Surfaces Static and Dynamic Contact Lines," Annual Review of Fluid Mechanics 11:371-400 (1979).
Probstein, "Physiochemical Hydrodynamics," (1989).
R.F. Service, "The Incredible Shrinking Laboratory," Science 268:26-27 (1995).
Presentation at Cold Spring Harbor (Aug. 31-Sep. 2, 1995).
R. Nowak, "Xeroxing DNA Analysis".
Manz, A. et al., "Electroosmotic pumping and electrophoretic separations for miniaturized chemical analysis systems" J. Micromech. Microeng. 4:257-265 (1994).
Wooley and Mathies, "Ultra-High-Speed DNA Sequencing Using Capillary Electrophoresis Chips," Anal. Chem. 67:3676-3680 (1995).
Effenhauser et al., "Manipulation of Sample Fractions on a Capillary Electrophoresis Chip," Anal. Chem. 67:2284-2287 (1995).
Van der Moolen, J.N. et al., "A Micromachined Injection Device for CZE: Application to Correlation CZE" Anal. Chem., 69:4220-4225 (1997).
P.B. Hieptas et al., "Ultrathin Slab Gel Separations of DNA Using Single Capillary Sample Introduction System," Anal. Chem. 69:2292-2298 (1997).
Z. Liang et al., "Microfabrication of a Planar Absorbance and Florescence Cell for Integrated Capillary Electrophoresis Devices," Anal. Chem. 68:1040-1046 (1996).

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