Thermal cycler for automatic performance of the polymerase...

Chemistry: molecular biology and microbiology – Apparatus – Including condition or time responsive control means

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S303100, C435S809000, C422S943000, C700S269000, C700S274000, C700S300000

Reexamination Certificate

active

10691186

ABSTRACT:
An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.

REFERENCES:
patent: 4480981 (1984-11-01), Togawa et al.
patent: 4499879 (1985-02-01), Stoltman et al.
patent: 4814787 (1989-03-01), Doi
patent: 4865986 (1989-09-01), Coy et al.
patent: 5061630 (1991-10-01), Knopf et al.
patent: 5475610 (1995-12-01), Atwood et al.
patent: 6015534 (2000-01-01), Atwood
patent: 6703236 (2004-03-01), Atwood
patent: 8808738 (1988-09-01), None
patent: 0 318 255 (1989-05-01), None
patent: 0 342 155 (1989-11-01), None
patent: WO 89/09437 (1989-10-01), None
Dewdney. “Newtons's Law of Cooling as a Laboratory Introduction to Exponential Decay Functions.” American Journal of Physics. Vol. 27 (Dec. 1959), No. 7, pp. 668-669.
Van Nostrand. Van Nostrand's Scientific Encyclopedia. D. Van Nostand Company, Inc. Princeton, NJ (1958), pp. 620 and 1116.
European Search Report, mailed Jun. 30, 2004, for European Application No. EP 04005554.3.
Oliver, Diane G., et al. “Thermal Gradients in Microtitration Plates, Effects of Enzyme-Linked Immunoassay”, Journal of Immunological Methods, Vol. 42, 1981, pp. 195-201.
Disclosure of Testimony of Shariar Motakef, Ph.D. Pursuant to Fed. R. Civ. P26(A)(2), re: The Perkin-Elmer Corporation and Roche Molecular Systems, Inc. v. MJ Research, Inc., In the United States District Court for the District of Connecticut, Case No. 3-98-CV-1201 DJS, dated Sep. 27, 2000.
Supplemental Disclosure of Testimony of Shariar Motakef, Ph.D. Pursuant to Fed. R. Civ. P26(A)(2), re: The Perkin-Elmer Corporation and Roche Molecular Systems, Inc. v. MJ Research, Inc., In the United States District Court for the District of Connecticut, Case No. 3-98-CV-1201 DJS, dated Sept. 27, 2000.
Verdict Form re: Applera Corporation and Roche Molecular Systems, Inc. v. MJ Research Inc. and Michael and John Finney, In the United States District Court for the District of Connecticut, 3:98-CV-1201 (JBA), dated Apr. 2, 2004.
Claim Construction of Disputed Terms in U.S. Patents 5,333,675, 5,656,493, and 5,475,610, re: Applera Corporation and Roche Molecular Systems, Inc. v. MJ Research inc. and Michael and John Finney, In the United States District Court for the District of Connecticut, 3:98-CV-1201 (JBA), dated Nov. 19, 2003.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Thermal cycler for automatic performance of the polymerase... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thermal cycler for automatic performance of the polymerase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thermal cycler for automatic performance of the polymerase... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3812479

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.