Thermal-assisted electrospray interface (TAESI) for LC/MS

Details Thermal-assisted electrospray interface (TAESI) for LC/MS Thermal-assisted electrospray interface (TAESI) for LC/MS

1988-06-03

1990-06-19

Berman, Jack I.

Radiant energy

Ionic separation or analysis

With sample supply means

250281, 250282, H01J 4910

Patent

active

049356240

ABSTRACT:
A Thermal-Assisted Electrospray Interface (TAESI) used in series between a liquid chromatograph and a mass analyzer gives increased sensitivity for detection of components in a liquid stream at high flow rates up to 2 milliliters per minute. Liquid exiting the liquid chromatograph is sprayed through a stainless steel capillary tube while being heated externally and under an applied voltage of about 3 KV. The combination of thermal energy and electric field potential disperses the liquid into a fine mist which is then directed at atmospheric pressure into the ionization chamber of a mass spectrometer. Such a system, optionally may additionally contain a high velocity gas flow neubulization means.
The TAESI interface may be used without the electric field; however at flow rates of from 500 to 1000 .mu.L/min the use of both electric field and thermal energy increases the sensitivity by two orders of magnitude over the interface used without the electric field.

REFERENCES:
patent: 4298798 (1981-11-01), Takeuchi et al.
patent: 4546253 (1985-10-01), Tsuchiya et al.
patent: 4730111 (1988-03-01), Vestal et al.
patent: 4794252 (1988-12-01), Bateman et al.
Fenn, J. B. et al., Science, 246:64-71, (1989).
Lee, E. et al., J. Chromatogr, 458:313, (1988).
Covey, T. R. et al., Rapid Common. Mass Spectrom., 2:249, (1988).
Lee E. D. et al., Journal of Microcolumn Separations, 1:14, (1989).
Bruins, A. D. et al., Anal. Chem., 59:2647, (1988).

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