Therapy using glucosidase processing inhibitors

Details Therapy using glucosidase processing inhibitors Therapy using glucosidase processing inhibitors

1985-07-09

1989-06-06

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 23, 514283, 514345, 514729, 514738, 436 63, 436 64, A61K 3170, G01N 3348

Patent

active

048372374

ABSTRACT:
A method of regulating oncogene-mediated cell transformation in a mammalian host. Oncogenes having glycosylated expression products are regulated by administering an effective amount of a processing glucosidase inhibitor: a glucosidase I inhibitor, e.g., castanospermine, N-methyl-1-deoxynojirimycin, 1-deoxynojirimycin, 5-amino-5-deoxy-D-glucopyranose; or a glucosidase II inhibitor, e.g., bromoconduritol. The glucosidase I inhibitors are preferred, particularly castanospermine (CA) and N-methyl-1-deoxynojirimycin (MdN). Oncogenes having glycosylated expression products that are ultimately expressed on the plasma membrane or secreted from transformed cells are particularly susceptible to regulation by these anti-cancer drugs. Also provided is a method of regulating the immune system of a mammalian host. Administration of an effective amount of a processing glucosidase inhibitor suppresses proliferation and differentiation of monocytic and myeloblastic cells.

REFERENCES:
Pinter, A. et al., "Studies with Inhibitors of Oligosaccharide Processing Indicate a Functional Role for Complex Sugars in the Transport and Proteolysis of Friend Mink Cell Focus-Inducing Murine Leukemia Virus Envelope Proteins", Virology, vol. 136, pp. 196-210, 1984.
Pan, Y. T. et al., "Castanospermine Inhibits the Processing of the Oligosaccharide Portion of the Influenza Viral Hemagglutinin", Biochemistry, pp. 3975-3984, 1983.
Virology 132:95-109, 1984.
Molecular and Cellular Biology 4(10): 1999-2009, Oct. 1984.
Proc. Natl. Acad. Sci. U.S.A. 81: 85-89, Jan. 1984.
TIBS, pp. 32-33, Jan. 1984.
The EMBO Journal 4(1): 105-112, 1985.
Cell 40: 971-981, Apr. 1985.
Cell 39: 327-337, Dec. 1984 (Part 1).

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