Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2003-02-12
2009-02-10
Shiao, Rei-tsang (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
07488749
ABSTRACT:
The present invention relates to 5,6-dihydroxyindole (DHI), 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and/or 5-S-cysteinyldopa (CD) as medicaments, as well as their use, and the use of tyrosinase for the preparation of a medicament for prophylaxis or therapy of diseases induced by oxidative stress. Furthermore, the present invention relates to the use of gene therapy vectors comprising a tyrosinase gene. Further, the present invention relates to cells modified by a tyrosinase gene.
REFERENCES:
patent: 5126125 (1992-06-01), Pawelek
patent: 5686084 (1997-11-01), Wenke et al.
patent: 6022526 (2000-02-01), Woodburn et al.
patent: WO 92/07580 (1992-05-01), None
patent: WO 00/10507 (2000-03-01), None
patent: WO 02/066620 (2002-08-01), None
Novellino et al., Chem. Res. Toxicol, 1999, 12:985-992.
ExPASy database. (1999).
Barrenas and Lindgren, “The influence of eye colour on susceptibility to TTS in humans,”Br J Audiol, 25(5):303-307, 1991.
Dorey et al., “Evidence of melanogenesis in porcine retinal pigment epithelial cells in-vitro,”Experimental Eye Research, 50(1):1-10, 1990.
Ebadi et al., “The antioxidant properties of zinc and metallothionein,”Neurochem Int, 29(2):159-166, 1996.
Frank et al., “Antioxidant enzymes in the macular retinal pigment epithelium of eyes with neovascular age-related macular degeneration,”Am J Ophthalmol, 127:694-709, 1999.
GenBank Accession No. M27160. , 1996.
Orlow, “Melanosomes are specialized members of the lysosomal lineage of organelles,” J Invest Dermatology, 105(1):3-7, 1995.
Peters et al., “Characteristics and functions of melanin in retinal pigment epithelium,”Der Ophthalmologe: Zeitschrift der Deutchen Ophthalmologischen Gesellschaft, 98(12):1181-1185, 2001.
Rimbach et al.,“Zinc—update of an essential trace element,”Ernährungswiss, 35(2):123-142, 1996.
Schraermeyer and Heimann, “Current understanding on the role of retinal pigment epithelium and its pigmentation,”Pigment Cell Res, 12:219-236, 1999.
Schraermeyer et al., “Up-regulation of tyrosinase in adult mammalian retinal pigment epithelium by phagosytosis of rod outer segments,” 15(Supp 9), XVIII International Pigment Cell Conference, Egmond aan Zee, Netherlands, Sep. 9-13, 2002.
Tate et al., “Zinc protects against oxidative damage in cultured human retinal pigment epithelial cells,”Free Radic Biol Med, 26(5-6):704-713, 1999.
Cevec Pharmaceuticals GmbH
Fulbright & Jaworski LLP
Shiao Rei-tsang
LandOfFree
Therapy of diseases of the eye, the inner ear and the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Therapy of diseases of the eye, the inner ear and the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapy of diseases of the eye, the inner ear and the... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4135755