Therapy by vesicle delivery to the hydroxyapatite of bone

Details Therapy by vesicle delivery to the hydroxyapatite of bone Therapy by vesicle delivery to the hydroxyapatite of bone

1988-08-25

1990-07-17

Thexton, Matthew A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

4284022, 424450, A61F 200, A61K 3722, B01J 1302

Patent

active

049420364

ABSTRACT:
A known procedure is used to prepare vesicles consisting of bipolar lipid membranes which are permeable and hence "leak" their contents at a rate which is variable by choice.
The vesicle is supplied with medication or diagnostic material and then attached to a target molecule conjugate that has affinity for the hydroxyapatite of bone.
Thus, the vesicle clings to the skeleton structure and bathes the surrounding support surface with its contents for extended hours.

REFERENCES:
patent: 4193983 (1980-03-01), Ullman et al.
patent: 4501728 (1985-02-01), Geho et al.
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4603044 (1986-07-01), Geho et al.
patent: 4692433 (1987-09-01), Hostetler et al.
patent: 4698328 (1987-10-01), Neer et al.
patent: 4767615 (1988-08-01), Geho et al.

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