Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1993-03-24
1996-02-06
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 15, 435 911, 435 915, 536 2433, 436 64, 935 77, C12Q 168, C12P 1934, C07H 2104
Patent
active
054895081
ABSTRACT:
Method and compositions are provided for the determination of telomere length and telomerase activity, as well as the ability to inhibit telomerase activity in the treatment of proliferative diseases. Particularly, primers are elongated under conditions which minimize interference from other genomic sequences, so as to obtain accurate determinations of telomeric length or telomerase activity. In addition, compositions are provided for intracellular inhibition of telomerase activity.
REFERENCES:
patent: 4737454 (1988-04-01), Dattagupta et al.
Harley, "Telomere Loss: Mitotic Clock or Genetic Time Bomb?" 256 Nature 271, 1991.
Yu et al., "Developmentally Programmed Healing of Chromosomes by Telomerase in Tetrahymena", 67 Cell 823, 1991.
Harley et al., "Telomeres Shorten During Ageing of Human Fibroblasts" 345 Nature 458, 1990.
Blackburn, "Structure and Function of Telomeres", 350 Nature 572, 1991.
Cech, "Ribozymes and Their Medical Implications", 260 Jnl of Amer. Med. Assoc. 3030, 1988.
Eck and Nabel, "Antisense oligonucleotides for therapeutic intervention", 2 Current Opin. in Biotech 897, 1991.
Zahler et al., "Inhibition of Telomerase by G-quartet DNA Structures", pp. 718-720, Nature, vol. 350, (Apr. 25, 1991).
Harley, Mutation Research (Nov. 1991) 256:271-282.
Counter et al., EMBO J, (May 5, 1992) 11:1921-1929.
Greider et al., (1991) Molecular Cellular Biology 11:4572-4580.
Blackburn et al. Genome (1989) 31:553-560.
Greider et al. (1987) Cell 51:887-898.
Greider and Blackburn, "A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis," Nature 337:331-337 (1989).
Cotten, "The in vivo application of ribozymes," Trends in Biotechnology 8:174-178 (1990).
Harley et al., "The Telomere Hypothesis of Cellular Aging," Experimental Gerontology 27:375-382 (1992).
Shay et al., "Loss of telomeric DNA during aging may predipose cells to cancer (Review)," Int'l J. Oncology 3:559-563 (1993).
Windle and McGuire, "Telomeres: the long and the short of it," Proceedings of the American Association for Cancer Research 33:594-595 (1992).
Counter et al., "Stabilization of Short Telomeres and Telomerase Activity Accompany Immortalization of Epstein-Barr Virus-Transformed Human B Lymphocytes," J. Virology 68:3410-3414 (1994).
Klingelhutz et al., "Restoration of Telomeres in Human Papoillomavirus-Immortalized Human Anogenital Epthelial Cells," Molecular and Cellular Biology 14:961-969 (1994).
Counter et al., "Telomerase activity in human ovarian carcinoma," Proc. Natl. Acad. Sci. USA 91:2900-2904 (1994).
Strahl and Blackburn, "The effects of Nucleoside analogs on telomerase and telomeres in Tetrahymena," Nucleic Acids Research 22:893-900 (1994).
Shay Jerry
West Michael D.
Wright Woodring
Jones W. Gary
Kaster Kevin
Myers Carla
Stark Amy
University of Texas System Board of Regents
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