Therapies involving mutated heat shock transcription factor

Details Therapies involving mutated heat shock transcription factor Therapies involving mutated heat shock transcription factor

2006-05-30

2006-05-30

McKelvey, Terry (Department: 1636)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S04400A

Reexamination Certificate

active

07053052

ABSTRACT:
The present invention relates to exogenous mutant HSF (mutHSF encoded by exogenous DNA) alters expression or synthesis of endogenous heat shock protein (hsp) genes in eukaryotic cells, tissues and organisms (e.g., mammalian, particularly human, cells, tissues and organisms). As described herein, mutHSF has been shown to regulate expression of endogenous hsp in cells and, as a result, to alter the response of the cells to stress. The mutHSF of the present invention is either positively-acting mutHSF or negatively-acting mutHSF.

REFERENCES:
Zuo et al, Molecular and Cellular Biology, Aug. 1995, vol. 15, No. 8, pp. 4319-4330.

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