Therapeutics for management of cocaine induced toxicity

Details Therapeutics for management of cocaine induced toxicity Therapeutics for management of cocaine induced toxicity

1993-09-24

1995-08-15

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514565, 514554, 514406, 514646, 514812, A61K 3122, A61K 31195

Patent

active

054419824

ABSTRACT:
Repetitive administrations of cocaine over a period of days causes the animal body to become more sensitive to the drug. A dose of cocaine that was not toxic to a novice user may be toxic or even lethal to an habituated user. These toxic effects include craving, seizures, brain ischemia and death. The mechanism of action of these toxic effects appears to be through the glutamatergic neurotransmitter system as evidenced by blocking with antagonists for N-methyl-D-aspartate receptors. However, these antagonists have undersirable side effects. Applicant demonstrates that the toxic effects of repetitive cocaine administrations can be reversed by the administration of inhibitors of the enzyme nitric oxide synthase which is also involved in the neurotransmitter system. The drugs which inhibit the enzyme nitric oxide synthase include N-nitro-L-arginine and N-nitro-L-arginine methyl ester. The method of treatment with these drugs includes administration in various forms by various routes.

REFERENCES:
patent: 5225440 (1993-07-01), London et al.
Journal of Pharmacology texperimental Therapeutics v. 262 *2, pp. 464-470 Itzhakttstein, 1992 "Sensit.to toxic effects of cocaine in mice . . . ".
1989 Life Sciences v. 45, pp. 599-606, Karla et al, "Blockade of Reverse Tolerance".
1991 European Journal of Pharm. 204 (1991) 339-340 Nowicki et al., "Nitric Oxide . . .".
Pudiak et al., "L-Name and MK-801 Attenuate Sensitization . . . ", Life Sciences, vol. 53, pp. 1571-1524 (1993).
Embase Abstract 93324192, Kimes et al., Psychopharmacology 112/4, pp. 521-524 (1993).
Embase Abstract 93242193, Thorat et al., Brian Research, 621/1, pp. 171-174 (1993).
Chemical Abstracts 117(25):245479a, Kolesnikov et al., Eur. J. Pharmacol., 221 (2-3), pp. 399-400 (1992).

Affiliated with

Also associated with

Rating

Therapeutics for management of cocaine induced toxicity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutics for management of cocaine induced toxicity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutics for management of cocaine induced toxicity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2182053