Therapeutically useful N-phenylaniline derivatives

Details Therapeutically useful N-phenylaniline derivatives Therapeutically useful N-phenylaniline derivatives

1979-03-14

1980-09-16

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

424319, 562456, 562457, 560 43, 549 72, C07C101447, A61K 31195, A61K 3138

Patent

active

042230390

ABSTRACT:
There are provided compounds of the general formula ##STR1## in which Ar represents a phenyl group which is unsubstituted or substituted by a halogen atom or a lower alkyl group, or represents a thienyl group, R.sub.1 represents a hydrogen or halogen atom or, when the Ar--CO-- grouping is in the meta-position with respect to the nitrogen atom, a lower alkyl group, R.sub.2 represents a hydrogen atom, or a lower alkyl or an acyl group, and R.sub.3 represents a hydrogen atom, a lower alkyl or a phenyl group and a physiologically acceptable salt thereof.
The compounds of the general formula I and their salts have therapeutic utility, especially as analgesics.

REFERENCES:
patent: 3531467 (1970-09-01), Archer et al.
patent: 3642887 (1972-02-01), Jackisch
patent: 3781095 (1973-12-01), Klemm et al.
patent: 4034111 (1977-07-01), Schoetenslack et al.
patent: 4069344 (1978-01-01), Kauer
patent: 4072705 (1978-02-01), Mieville
patent: 4153718 (1979-05-01), Goudie
Simonor et al., Chem. Abst., vol. 83, #113985g (1975).

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