Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-01-13
1981-02-24
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544141, 544137, 4242485, 544124, 42424855, 544111, 544121, 42424856, 544128, 544130, 424246, 544131, 544105, 424250, 544 91, 26032643, 424263, 560 29, 560 31, 424267, 560 32, 560 27, 424272, 564188, 564164, 424274, 564165, 564 34, 424285, 564143, 260239B, 424283, 546237, 546233, 544382, 546221, 546308, 544394, 548240, 546159, 544393, 546143, 2603473, 544399, 2603457R, 564189, 544389, 564191, 564194, 544 584, 564 52, 564 79, 544165, 564142, 564167, 544172, 544 581, 544 85, 544 86, 544158, 544159, 544168, 544
Patent
active
042528046
ABSTRACT:
Compounds of the formula I ##STR1## wherein m and n are 0, 1 or 2, X represents oxygen, imino, benzylimino, or morpholinoethylimino, Y represents CO, CONH, COO or SO.sub.2, and NR.sub.1 R.sub.2 represents a dimethylamino, diethylamino, dipropylamino, dibutylamino, allylamino, isobutenylamino, cyclopentylamino, cyclohexylamino, cycloheptylamino, cyclooctylamino, N-methyl N-cyclopentylamino, N-methyl N-cyclohexylamino, N-allyl N-cyclohexylamino, adamantylamino, diethoxyethylamino, dimethylaminoethylamino, dimethylaminopropylamino, N-methyl N-dimethylaminopropyl-amino, benzylamino, 3,4,5-trimethoxybenzylamino, phenethylamino, p-chlorophenethylamino, tetrahydrofurfurylamino, tetrahydropyranylmethylamino, pyrrolidino, isoxazolidinyl, piperidino, 4-hydroxypiperidino, 4-m-chlorophenyl-4-hydroxypiperidino, homopiperidino, 1,2,3,6-tetrahydropyridyl, morpholino, 2-methylmorpholino, 2,6-dimethylmorpholino, 2-morpholinoethylamino, thiamorpholino, piperazino, 4-methylpiperazino, 4-(.alpha.-m-chlorophenyl-benzyl)-piperazino, 4-(3,4,5-trimethoxyphenylaminocarbonyl)-piperazino, 4-(3,4,5-trimethoxyphenylaminocarbonylmethyl)-piperazino, 4-phenylpiperazino, 4-m-trifluoromethylphenyl-piperazino, 4-piperidinocarbonylmethyl-piperazino, 1,2,3,4-tetrahydroquinolyl, 1,2,3,4-tetrahydroisoquinolyl, (7-chloro-4-quinolyl)-amino, 1,2,3,4-tetrahydrobenzoxazinyl or 1,2,3,4-tetrahydro-6-chlorobenzoxazinyl group, and their pharmaceutically acceptable acid addition salts are novel and are therapeutically useful, in particular as tranquillizers, myorelaxants and anticonvulsants.
REFERENCES:
patent: 2870145 (1959-01-01), Perron
patent: 2870146 (1959-01-01), Perron
patent: 2882273 (1959-04-01), Holdrege
patent: 3234276 (1966-02-01), Petracek
patent: 3562262 (1971-02-01), Schmidt et al.
patent: 3729470 (1973-04-01), Vaille
patent: 3755317 (1973-08-01), Pifferi
Chemical Abstracts, vol. 71, Item 29134(y) (1969), abstracting Green et al., in "J. Pharm. Pharmacol." (1969), vol. 21, No. 6, pp. 366-373.
Joullie Maurice
Lakah Lucien
Maillard Gabriel
Warolin Christian J. M.
Bond Robert T.
Hueschen Gordon W.
Jiles Henry R.
Metabio-Joullie
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