Therapeutically effective peptides related to preproinsulin

Details Therapeutically effective peptides related to preproinsulin Therapeutically effective peptides related to preproinsulin

2006-05-23

2006-05-23

Carlson, Karen Cochrane (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S013800, C514S014800, C530S303000, C530S324000, C530S326000

Reexamination Certificate

active

07049292

ABSTRACT:
A peptide having a sequence comprising or consisting of QPLALEGSLQK.

REFERENCES:
patent: 2002/0058614 (2002-05-01), Filvaroff et al.
patent: WO 9634882 (1996-11-01), None
Peakman, M., Stevens, E.J., et al. 1999. Naturally Processed and Presented Epitopes of the Islet Cell Autoantigen 1A-2 eluted from HLA-DR4. J. Clin. Invest. 104(10):1449-1457.
Meierhoff, G., Ott, P.A., et al. 2002. Cytokine detection by ELISPOT: relevance for immunological studies in type 1 diabetes. Diabetes Metab. Res. Rev. 18: 367-380.
Herold, K. C.; “Achieving Antigen-Specific Immune Regulation”;The Journal of Clinical Investigation; vol. 113, No. 3; pp. 346-349 (2004).
Schloot, N.C., et al; “Comparison of Cytokine ELISpot Assay Formats for the Detection of Islet Antigen Autoreactive T Cells Report of the Third Immunology of Diabetes Society T-Cell Workshop”;Journal of Autoimmunity; vol. 21; pp. 365-376 (2003).
Arif, S., et al; “Autoreactive T Cell Responses Show Proinflammatory Polarization in Diabetes but a Regulatory Phenotype in Health”;The Journal of Clinical Investigation; vol. 113, No. 3; pp. 451-463 (2004).
Congia, M., et al; “T Cell Epitopes of Insulin Defined in HLA-DR4 Transgenic Mice are Derived from Preproinsulin and Proinsulin”;Proc. Natl. Acad. Sci.; vol. 95; pp. 3833-3838 (1998).
Durinovic-Bello, I., et al; “Predominantly Recognized ProInsulin T Helper Cell Epitopes in Individuals With and Without Islet Cell Autoimmunity”;Journal of Autoimmunity; vol. 18, pp. 55-66; (2002).
Astill, Tom; “Characterisation of T Cell Epitopes of Proinsulin in Type 1 Diabetes”; Selected Portion of a PhD Thesis; Figures refer to the sequence claimed—the thesis text is as for the Arif et al (2004) publication.
Congia, M., et al; “T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin”;Proc. Natl. Acad. Sci. USA; vol. 95, No. 7; pp. 3833-3838, Mar. 31, 1998; XP-002204284.
Geluk, A., et al; “HLA-DR Binding Analysis of Peptides from Islet Antigens in IDDM”;Diabetes; vol. 47, No. 10; pp. 1594-1601, Oct. 1998; XP-002323217.
Narendran, P., et al; “Humoral and cellular immune responses to proinsulin in adults with newly diagnosed type 1 diabetes”;Diabetes/Metabolism Research and Reviews; vol. 19, No. 1; pp. 52-59; Oct. 28, 2003; XP-002323390.
Liberman, S.M., et al; “A comprehensive guide to antibody and T-cell responses in type 1 diabetes”;Tissue Antigens; vol. 62, No. 5; pp. 359-377; Nov. 2003; XP-002323391.
Meierhoff, G., et al; “Cytokine detection by ELISPOT: relevance for immunological studies in type 1 diabetes”;Diabetes/Metabolism Research and Reviews; vol. 18, No. 5, pp. 367-380; Oct. 2002; XP-002323218.
Peakman, M., et al; “Naturally processed and presented epitopes o the islet cell autoantigen IA-2 eluted from HLA-DR4”;The Journal of Clinical Investigation; vol. 104, No. 10; pp. 1449-1457; Nov. 1999; XP-002323392.
Durinovic-BEIIo, I., et al; “Predominantly Recognized Proinsulin T Helper Cell Epitopes in Individuals With and Without Islet Cell Autoimmunity”;Journal of Autoimmunity; Vo. 18; pp. 55-56; (2002).

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