Therapeutically active mixture of glutathione and anthocyanin co

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530331, A61K 3800

Patent

active

059256206

ABSTRACT:
A mixture of substances for therapeutically treating the human or animal body contains reduced glutathion and at least an anthocyan compound from the group composed of pelargonidine, peonidine, cyanidine, melvidine, petunidine and delphinidine. The reduced glutathion can be entirely or partially substituted by at least a thiol-derivate of glutathion from the group composed of methyl-glutathionyl-(thio)-ether, ethylglutathionyl-(thio)-ether, mono-acetyl-glutathionyl-(thio)-ester and mono-phosphoric acid glutationyl-(thio)-ester.

REFERENCES:
patent: 2760956 (1956-08-01), Brick
patent: 3984569 (1976-10-01), Kalopissis et al.
patent: 4229439 (1980-10-01), Majole
patent: 4258055 (1981-03-01), Lietti et al.
patent: 4413004 (1983-11-01), Lietti et al.
Raynal et al., J. Agric. Food Chem., 37, pages 1051-1053, 1989.
Vince and Wadd, "Glyoxalase Inhibitors as Potential Anticancer Agents," Biochem. and Biophys. Res. Comm., 35(5):593 (1969).
Ohlenschlager et al., "Die Lipidperoxidation --ein fur viel Erkrankungen grundlegendes pathobiochemisches Problem" (The Lipidperoxidation --a basic pathobiological problem concerning many diseases), Arztezeitschr. f. Nat. u. Reg. Sep. 1989, 30 Jhrg. Scientific Journal for Natural Medicine, pp. 713-727.
Brunmark et al., "Redox and Addition Chemistry of Quinoid Compounds and its Biological Implications," Free Radical Biology & Medicine, vol. 7, pp. 435-477, 1989.
Flohe et al., "Protective Function of Reduced Glutathione (G-SH) Against the Effect of Prooxidative Substances and of Irradiation in the Red Cell," Glutathione --Proceedings of the 16th Conference of the German Society of Biological Chemistry, Tubingen, pp. 192-199, George Thieme Publishers Stuttgart, 1974.
Larsson et al., "Functions of Glutathione Biochemical, Physiological, Toxicological, and Clinical Aspects," Raven Press, New York, 1983, pp. 51-64, 99-108, 125-137, 149-161, 163-173, 199-203, 205-213, 215-222, 231-242, 243-250, 251-260, 261-271, 297-305, and 307-315.
Ohlenschlager, "Tumorproliferation and Tumorprogression," Therapeutikon 10, 555-568, Oct. 1988.
Ohlenschlager, "Umweltbelastung und Krebserkrankungen" (Environmental Pollution and Cancer), Natur-und Ganzheitsmedizin, 4, pp. 18-21, Apr. 1991.
Ohlenschlager et al., "Die Selen-abhangigen Glutathion-Peroxidasen" (The Selenium-dependent Glutathione Peroxidase), Natur-und GanzheitsMedizin, 4, pp. 258-265, Apr. 1991.
Ohlenschlager et al., "Freie Radikale -aktivierte Sauerstoff-Stufen und das Phanomen der Lipidperoxidation" (Free Radicals --Activated Oxygen-Levels and the Phenomenon of Lipid Peroxidation), Natur-und GanzheitsMedizin, 3, pp. 381-391, Mar. 1990.
Ohlenschlager et al., "Wie frei sind ,,freie" Radikale in lebenden Systemen?" (How Free are "Free" Radicals in Living System?), Erfahrungsheilkunde, pp. 55-70, Feb., 1988
Smith, "Correlations and Apparent Contradictions in Assessment of Oxidant Stress Status in Vivo," Free Radical Biology & Medicine, vol. 10, pp. 217-224, 1991.
Mannervik et al., "The Catalytic Mechanism of Glutathione Reductase," Flavins and Flavoproteins, Bd. 6, 1980, pp. 173-188.
A.M. Novi, "Regression of Aflatoxin B.sub.1 -Induced Hepatocellular Carcinomas by Reduced Glutathione," Science, vol. 212 (4494):541 (May, 1981).
J.P. Perchellet et al., "Effects of Combined Treatments with Selenium, Glutathione, and Vitamin E on Glutathione Peroxidase Activity, Ornithine Decarboxylase Induction, and Complete Multistage Carcinogenesis in Mouse Skin," Cancer Research, 47(2):477, Jan. 15, 1987.
M.E. Anderson et al., "Glutathione Monoethyl Ester: Preparation, Uptake by Tissues, and Conversion to Glutathione," Arch. of Biochemistry and Biophysics, vol. 239(2):538 (Jun., 1985).
E. Beutler et al., "Plasma Glutathione in Health and in Patients with Malignant Disease," J. Lab. Clin. Med., 105:581 (May, 1985).
Kuhnau, "The Flavonoids. A Class of Semi-Essential Food Components: Their Role in Human Nutrition," Wld Rev. Nutr. diet., vol. 24, pp. 117-191 (1976).
Hagen et al., "Bioavailability of dietary glutathione: effect on plasma concentration," Amer. Physiological Society, pp. 524-529, 1990.
Maellaro et al., "Lipid peroxidation and antioxidant systems in the liver injury produced by glutathione depleting agents," Biochem Pharmacol, 39(10):1513-1521 (May 15, 1990) (Abstract only).
Bland et al., medical Applications of Clinical Nutrition, pp. 46-47 (1983).
"Vitamin A, Beta-Carotene and other Carotenoids," Vitamin A & Carotenoids, Textbook of Natural Medicine, vol. 1, 1986, pp. 1-11.
Reed, et al., "Glutathione Depletion and Susceptibility," Pharmacological Reviews, pp.25S-33S, 1984.
Werbach, Nutritional Influences on Illness, pp. 120, 140-141, 158, 201.
Minkova et al., "Antiradiation Properties of Alpha Tocopherol, Anthocyans, and Pyracetam Administered Combined as a Pretreatment Course," Bulgarian Academy of Sciences, pp. 31-35, 1990.
"Guarding Against Cellular Glutathione Deficiency," Nutrition Reviews, vol. 48, No. 9, pp. 346-348, Sep., 1990.
Di Re et al., "Efficacy and safety of high-dose cisplatin and cyclophosphamide with glutathione protection in the treatment of bulky advanced epithelial ovarian cancer," Cancer Chemother Pharmacol, 25:355-360 (1990).
Nobile et al., "A Preliminary Clinical Study of Cyclophosphamide with Reduced Glutathione as Uroprotector," Tumori, 75:257-258 (1989).
Cutler, "Antioxidants and Aging," Am. J. Clin. Nutr., 53:373-379 (1991).
Corbucci et al., "Shock-Induced Damage to Mitochondrial Function and Some Cellular Antioxidant Mechanisms in Humans," Circulatory Shock, 15:15-26 (1985).
Keller et al., "Decreased Hepatic Glutathione Levels in Septic Shock," Arch Surg, vol. 120, pp.941-945 (Aug., 1985).
Shi et al., "Factors influencing hepatic glutathione concentrations: a study in surgical patients," Clinical Science, 62:279-283 (1982).
Ferrari et al., "Role of oxygen free radicals in ischemic and reperfused myocardium," Am J Clin Nutr, 53:215-222 (1991).
Tedeschi et al., "The role of glutathione in combination with cisplatin in the treatment of ovarian cancer," Cancer Treatment Reviews, 18:253-259 (1991).
Lash et al., "Exogenous glutathione protects intestinal epithelial cells from oxidative injury," Proc. Natl. Acad. Sci., vol. 83, pp.4641-4645, (Jul., 1986).
Meister, "Selective Modification of Glutathione Metabolism," Science, vol. 220, pp. 472-477 (Apr., 1983).
Vincenzini et al., "Glutathione-mediated transport across intestinal brush-border membranes," Biochimica et biophysica Acia, 942:107-114 (1988).
Braverman et al., "The Healing Nutrients Within --Facts, Findings and new Research on Amino Acids," p.93 (1987).
J. Molnar, et al.; Antitumor Activity of Flavonoids on NK/Ly Ascites Tumor Cells; Neoplasma, 28, 1, 1981, pp. 11-18.
Pharmacological Research Communications, vol. 18, No. 1, 1986, pp. 61-72.
Mou-Tuan Huang, et al.; Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids; Carcinogenesis vol. 4 No. 12, pp. 1631-1637, 1983.
Chemical Abstracts, vol. 105, 1986, Ref. 120591b.
Chemical Abstracts, vol. 108, 1988, Ref. 11248m.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Therapeutically active mixture of glutathione and anthocyanin co does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutically active mixture of glutathione and anthocyanin co, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutically active mixture of glutathione and anthocyanin co will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1321901

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.