Therapeutically active flavonyl-1,4-dihydrophyridines

Details Therapeutically active flavonyl-1,4-dihydrophyridines Therapeutically active flavonyl-1,4-dihydrophyridines

1986-10-22

1989-02-21

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514253, 514318, 514316, 514337, 5142325, 546269, 546187, 546193, 544131, 544365, A61K 31445, C07D40702

Patent

active

048065340

ABSTRACT:
The novel flavonyl-1,4-dihydropyridines having the general formula (I): ##STR1## are therapeutically effective calcium antagonists and smooth muscle relaxant.

REFERENCES:
patent: 2921070 (1960-01-01), da Re
patent: 4532248 (1985-07-01), Franckowiak et al.
Thomas et al. J. of Cardiovasular Phar. 6: 1170-1176 1984.
Schramm et al., Nature vol. 303. 9. Jun. 1983.
Bossert et al. Angew. Chem. Int. Ed. Engl. 20, 762-769 (1981).
"Novel dihydropyridines with positive inotropic action through activation of Ca.sup.2+ Channels," M. Schramm et al, Letters to Nature vol. 303, Jun. 9, 1983.
"Drug treatment of the overactive detrusor", K. E. Andersson et al, Acta pharmacol, et toxicol. 1980, 46 Suppl. I, (7-11).
"Effect of Calcium Channel Blockers on Urinary Tract Smooth Muscle", Karl Brik Andersson et al, Acta Pharmacol Toxicol 58 (supple. II), 1986.
"Anticholinergic and calcium antagonistic effects of terrodiline in rabbit urinary bladder", S. Husted, et al, Acta Pharmacol. et Toxicol 1980.46 (Suppl. I.) (20-30).

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