Therapeutically active derivatives of benzamide

Details Therapeutically active derivatives of benzamide Therapeutically active derivatives of benzamide

1979-07-19

1982-01-26

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

2603977R, 424309, 424319, 560 21, 560 22, 560 35, 562435, 562437, 562440, A61K 3163, A61K 3124, C07C14380, C07C10328

Patent

active

043128629

ABSTRACT:
Novel therapeutically active derivatives of benzamide, having the general formula ##STR1## in which R.sub.1 and R.sub.2, independently of each other, are hydrogen or a lower alkyl group, R.sub.3 is a phenyl or lower alkyl or lower alkenyl group, R.sub.4 is a halogen or a trifluoromethyl or nitro-group, R.sub.5 is a sulphamoyl or carboxyl or carboxy-alkyl group, and the potassium salts of these derivatives.
These compounds are diuretics and hypotensors (blood pressure depressants) and they lower the angiotensin and renin functions, with prolonged action.

REFERENCES:
Smith, T. A. Kilroe et al., Tetrahedron, vol. 1, (1957), pp. 38-44.
U.S. Adopted Drug Names; vol. NSB, No. 9, Sep. 1968, p. 511.

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