Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides with at least one nonpeptide bond other than a...
Patent
1984-03-29
1987-12-08
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Peptides with at least one nonpeptide bond other than a...
C07K 502, C07K 702
Patent
active
047119519
ABSTRACT:
Therapeutically active organic compound exhibiting at least one radical comprising a structure --S'--S"--R, where S"--R is defined by R being an organic group comprised in a physiologically acceptable compound H--S"--R obtainable by the splitting of the disulfide bridge --S'--S"-- in said structure, in which compound H--S"--R the sulfur atom S" is bound to a carbon atom in a heterocyclic aromatic ring in R having a configuration being such that the compound H--S"--R, while maintaining physiological acceptability, is stabilized, by tautomerism or resonance involving the sulfur atom S" bound to R, so as to be mainly excluded from further reaction involving thiol disulfide exchange; S' being bound to an aliphatic carbon atom; and said compound, in addition to the group or groups comprising the structure --S'--S"--R, also consisting of a residue of a therapeutically active organic base compound of polypeptide structure bound to S', for therapeutical use in mammals, including humans.
The invention also relates to a pharmaceutical composition containing as an active substance the compound mentioned above.
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Biochemical Journal vol. 133 No. 1 May 1973 Molecular Aspects pp. 67-80 JP-A-55-22657 (Patent Abstr.).
Axen Rolf E. A. V.
Carlsson Jan P. E.
Pharmacia Aktiebolag
Phillips Delbert R.
Philpitt Fred
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