Therapeutically active compound and pharmaceutical composition c

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides with at least one nonpeptide bond other than a...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07K 502, C07K 702

Patent

active

047119519

ABSTRACT:
Therapeutically active organic compound exhibiting at least one radical comprising a structure --S'--S"--R, where S"--R is defined by R being an organic group comprised in a physiologically acceptable compound H--S"--R obtainable by the splitting of the disulfide bridge --S'--S"-- in said structure, in which compound H--S"--R the sulfur atom S" is bound to a carbon atom in a heterocyclic aromatic ring in R having a configuration being such that the compound H--S"--R, while maintaining physiological acceptability, is stabilized, by tautomerism or resonance involving the sulfur atom S" bound to R, so as to be mainly excluded from further reaction involving thiol disulfide exchange; S' being bound to an aliphatic carbon atom; and said compound, in addition to the group or groups comprising the structure --S'--S"--R, also consisting of a residue of a therapeutically active organic base compound of polypeptide structure bound to S', for therapeutical use in mammals, including humans.
The invention also relates to a pharmaceutical composition containing as an active substance the compound mentioned above.

REFERENCES:
patent: B471617 (1976-02-01), Kamber et al.
patent: 3481917 (1969-12-01), Grant et al.
patent: 4144128 (1979-03-01), Hildebrand et al.
patent: 4149003 (1979-04-01), Carlsson
patent: 4220722 (1980-09-01), Rowley et al.
patent: 4231999 (1980-11-01), Carlsson
patent: 4232119 (1980-11-01), Carlsson
patent: 4237267 (1980-12-01), Okujama
patent: 4258193 (1981-03-01), Fujii
patent: 4351764 (1982-09-01), Birr
patent: 4430266 (1984-02-01), Frank
patent: 4444683 (1984-04-01), Kim et al.
Biochemical Journal vol. 133 No. 1 May 1973 Molecular Aspects pp. 67-80 JP-A-55-22657 (Patent Abstr.).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Therapeutically active compound and pharmaceutical composition c does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutically active compound and pharmaceutical composition c, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutically active compound and pharmaceutical composition c will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-23227

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.