Therapeutically active 2-aminoalkylthio-3H-1.5-benzodiazepines a

Details Therapeutically active 2-aminoalkylthio-3H-1.5-benzodiazepines a Therapeutically active 2-aminoalkylthio-3H-1.5-benzodiazepines a

1972-10-10

1976-01-20

Randolph, John D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602471M, 260268BC, 26029859, 26032681, 424244, 424248, 424250, 424267, 424274, C07D24312

Patent

active

039337936

ABSTRACT:
Novel derivatives of 3H-1,5-benzodiazepine and of their salts of addition with acids, including their quaternary ammonium salts, having the general formula: ##EQU1## are provided. Such compounds are effective therapeutically against a large spectrum of gram positive bacteria and APR8 influenza virus. The invention also provides a novel method of preparing compounds having the formula: ##EQU2## wherein R and R' are the same as above, by reacting orthophenylenediamine with a benzoyldithioacetic acid having the formula: ##EQU3## wherein R and R' are as defined above.

REFERENCES:
patent: 3595858 (1971-07-01), McManus
Elslager et al., "J. Het. Chem.," Vol. 5, pp. 609-613 (1968).
Archer et al., "J. Org. Chem.," Vol. 29, pp. 239-233 (1964).

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