Therapeutic uses of verapamil enantiomers

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules

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424456, 424457, 424464, 424468, 514646, 514821, A61K 920, A61K 948

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active

059322462

ABSTRACT:
Substantially single enantiomer (R or S) verapamil, or a pharmaceutically-acceptable salt thereof provides an improved treatment for patients having a condition susceptible to treatment with racemic verapamil and who are disposed to constipation.

REFERENCES:
patent: 5057304 (1991-10-01), Kretzschmar et al.
patent: 5733756 (1998-03-01), Zeitlin et al.
Van Meel, J.C.A., et al. (1983) "Differential inhibition of .alpha..sub.2 -adrenoceptor-mediated pressor responses by (+)-and (-)-verapamil in pithed rats" Journal Pharm. Pharmacol. 35:500-504.
Longstreth, James A., "Verapamil: A Chiral Challenge to the Pharmacokinetic and Pharmacodynamic Assessment of Bioavailability and Bioequivalence" (1983).
Raschack, M., and K. Engelmann (1983) "Calcium Antagonistic Activity and Myocardial Ischemic Protection by Both Stereoisomers of Verapamil" Adv. Miocardiol. vol. 4, pp. 505-512.
Chiba, S. et al. (1978) "Effects of Optical Isomers of Verapamil on SA Nodal Pacemaker Activity and Contractility of the Isolated Dog Heart" Jpn. Heart J. 19(3):409-414.
Rabkin, S.W. (1994) "Verapamil Has Antiarryhthmic Effects That are mediated in Brain Through Endogenous Opioids" J. Cardiovac. Pharmacol. 23(5):814-821.
Thandroyen, F.T., et al. (1986) "The Influence of Verapamil and its Isomers on Vulnerability to Ventricular Fibrillation During Acute Myocardial Ischemia and Adrenergic Stimulation in Isolated Rat Heart" J. Mol. Cell. Cardiol. vol. 18, pp. 645-649.
Raschack, M. (1976) "Relationship of Antiarrhythmic to Inotropic Actibity and Antiarrhythimic Qualities of the Optical Isomers of Verapamil" Nauyn-Schmiedeberg's Arch. Pharmacol. 294, 285-291.
Curtis, M.J., M.J.A. Walker (1986) "The Calcium Antagonist Potency Ratio of the Optical Enantiomers of Verapamil in a Variety of Preparations" Proc. West. Pharmacol. Soc. 29:295-297.
Curtis, M.J., M.J.A. Walker (1986) "The Mechanism of Action of the Optical Enantiomers of Verapamil Against Ischaemis-Induced Arrhythimias in the Conscious Rat" Br. J. Pharmac. 89, 137-147.
Berkow, R., and A.J. Fletcher (eds.) (1992) "Diseases of the Heart and Pericardium" in The Merck Manual of Diagnosis and Therapy, 16.sup.th edition, published by Merck Research Laboratories, pp. 474-477.
Nayler, W. G. and W.J. Sturrock (1983) "An Inhibitory Effect of Verapamil and Diltiazem on the Resease of Noradrenaline from Ischaemic and Reperfused Hearts" J. Mol. Cell. Cardiol. 16:331-344.
Arita, Makoto, and Tatsuto Kiyosue (1983) Modification of " Depressed Fast channel Dependent Slow Conduction" by Lidocaine and Verapamil in the Presence of Absence of Catecholamines Evidence for Alteration of Preferential Ionic Channels for Slow Conduction Japanese Circulation Journal 47:68-80.
Arita, Makoto, et al. (1983) "Nature of Residual Fast Channels" Dependent Action Potentials and Slow Conduction in Guinea Pig Ventricular Muscle and Its Modification by Isoproterenol" The American Journal of Cardiology, 51:1433-1440.
Watanabe, Hidehiko, et al. (1981) "Effects of Imipramine on Frequency-Force Relationship in Isolated Right Atrial Muscle of the Dog" Japan. J. Pharmacol. 31:289-291.
Surakitbanharn, Yosyong, et al. (1995) "Self-Association of Dexverapamil in Aqueous Solution" Journal of Pharmaceutical Sciences, 84(6):720-723.
Motzer, Robert, et al. (1995) "Phase I/II Trial of Dexverapamil Plus Vinblastine for Patients with Advanced Renal Cell Carcinoma" Journal of Oncology, 13(8):1958-1965.
Satoh, Keisuke, et al. (1980) "Coronary Vasodilator and Cardiac Effects of Optical Isomers of Verapamil in the Dog" Journal of Cardiovascular Pharmacology 2:309-318.
Simamora, et al. (1994) "Compatibility Studies of Intravenous Dexverapamil Formulations" Pharmaceutical Research, 11(10):S277 **abstract**.

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