Therapeutic uses of oligomers of 15-dehydroprostaglandin B.sub.1

Details Therapeutic uses of oligomers of 15-dehydroprostaglandin B.sub.1 Therapeutic uses of oligomers of 15-dehydroprostaglandin B.sub.1

1987-05-21

1989-07-25

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514530, A61K 3119

Patent

active

048514322

ABSTRACT:
This invention relates to the therapeutic uses of oligomers of 15-dehydroprostaglandin B.sub.1 and oligomers of 16, 16'-dimethyl-15-dehydro PGB.sub.1 and oligomers or other 16 carbon substituted 15-dehydro PGB.sub.1 compounds (hereinafter referred to as oligomers of PGB.sub.1) in tissue ischemia, hyposix and anoxia, (hereinafter referred to collectively as tissue ischemia) and in protecting isolated organs (hearts, kidneys etc.) and cells (whole blood, erythrocytes, platelets, etc.) during in vitro transfer and storage; and as a phamacological agent in abnormal conditions in humans and animals in which alteration in cellular calcium is a mediator in the disease process.

REFERENCES:
patent: 4153808 (1979-05-01), Polis et al.
patent: 4245111 (1981-01-01), Polis et al.
Polis et al., Proc. Nat. Acad. Sci., 63, 229 (1969), "Regeneration of Oxidative Phosphorylation in Aged Mitochandria".
Polis et al., Proc. Nat. Acad. Sci., 76, 1598, (1979), "Protection and Reactivation of Oxidative Phosphorylation in Mitochandria".
Serhan et al., The Journal of Immunology, 125, 2020, (1980), "PGB.sub.x a Prostaglandin Derivative Mimics th Action of the Calcium Larophone".
Ohnishi et al., Biochemical and Biophysical Research Communications, "Calcium Larophone Activity of a Prostaglandin B.sub.1 Derivative PGB.sub.x ".

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