Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-12-10
1997-12-30
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424 944, 42419511, 514 63, 514567, A61K 3140, A61K 4706, A61K 4746
Patent
active
057030510
ABSTRACT:
The invention is directed to the treatment of degenerative diseases of tissues which have lost melanin and which share a common embryological basis as tissues of the nervous system by the administration of an active substance which causes an increased concentration of melanin in the tissue. Such active substances include melanin, melanin variants, melanin analogs, melanin derivatives, tyrosinase, tyrosinase gene, melanin-concentrating hormone and combinations thereof. Examples of such diseases include Parkinson's disease, Alzheimer's disease, retinitis pigmentosa, schizophrenia and dementia. The invention is also useful in assisting in the repair of neurons in a mammal having neuron damage by administering an effective amount of an active substance which causes an increased concentration of melanin in the neuron to aid in nerve repair. The invention is further useful in protecting a mammal from a toxin-induced disease or from the adverse effects of a toxin by administering an effective amount of the active substance described above.
REFERENCES:
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Chemical Abstracts 108:71398u (1988) Abstracting Cancer Res (1987) 47(23) 6377-83 reference.
della-Cioppa, et al., "Melanin Production in Escherichia Coli from a Cloned Tyrosinase Gene", Biotechnology 8:634-638 (1990).
Coderre, et al., "Selective Delivery of Boron by the Melanin Precursor Analogue .sub.p Boronophenylalanine to Tumors Other Than Melanoma", Cancer Research 50: 138-141 (1990).
Mishima, et al., "Treatment of Malignant Melanoma by Selective Thermal Neutron Capture Therapy Using Melanoma-Seeking Compound", The Journal of Investigative Dermatology 92: 321S-325S (1989).
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Berliner David L
Erwin Robert L.
McGee David R.
Biosource Technologies, Inc.
Halluin Albert P.
Raymond Richard L.
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