Therapeutic uses of glandular kallikrein

Details Therapeutic uses of glandular kallikrein Therapeutic uses of glandular kallikrein

2007-03-27

2007-03-27

Saucier, Sandra E. (Department: 1651)

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

C435S212000, C435S219000, C514S825000

Reexamination Certificate

active

10162697

ABSTRACT:
An immunosuppressive peptide of 40 kDa molecular weight, isolated from the submandibular glands (SMG*) of rats, had the capacity to suppress immune reactions upon parenteral administration to rats and mice. The peptide was identified as glandular kallikrein (K1) by partial sequencing and by enzymatic activity.

REFERENCES:
patent: 5744487 (1998-04-01), Ohshima et al.
Croxatto, H.R., et al., 1979. Inhibition of urinary kallikrein excretion by semi-purified renin in the rat. Clinical Science 57: 243s-245s.
Wikipedia entry: “Kidney.” Accessed Jan. 31, 2005. http://www.wikipedia.org/wiki/kidney.
Catalog listing for anti-rat renin avaliable from Swant, Inc. Accessed Jan. 31, 2005. http://www.swant.com/Antibodies—renin.htm.
Faria AMC et al. 2005. Oral tolerance. Immunol Rev 206: 232-259.

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