Therapeutic uses of dynorphin

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...

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A61K 3700

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043615538

ABSTRACT:
A therapeutic method of using dynorphin comprises administering dynorphin to a host tolerant to narcotic analgesics. Practice of the therapeutic method provides that lower doses of a narcotic analgesic may be used, such as for patients requiring chronic treatment with narcotics to ease pain, and for treatment of narcotics addicts.

REFERENCES:
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Litchfield et al., J. Pharmacol. Exap. Ther., 96:99-113 (1949).
D'Amour et al., J. Pharmac. Exp. Ther., 72, pp. 74-79 (1941).
Goldstein et al., Proc. Natl. Acad. Sci. USA, vol. 76, No. 12, pp. 6666-6670 (1979).
Herman et al., Life Sciences, vol. 27, pp. 883-892 (1980).
Friedman et al., "Dynorphin: A Possible Modulatory Peptide on Morphine or .beta.-Endorphin Analgesia in Mouse", Europ. J. Pharmacology (in press).

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