Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-02-02
2011-10-11
Jarrell, Noble (Department: 1622)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S143000
Reexamination Certificate
active
08034818
ABSTRACT:
Therapeutic uses of a compound corresponding to the general formula (I):in which A=N or CR2; R2=H, F, OH, CN, CF3, C1-6-alkyl, C1-6-alkoxy; n=2 or 3 and m=2 when A=N; n=1, 2 or 3 and m=1 or 2 when A=CR2; B=covalent bond or C1-8-alkylene; R1=optionally substituted heteroaryl; R3=CHR4CONHR5; R4=H or C1-6-alkyl; R5=H, C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-C6-alkylene;in the form of a base, an acid-addition salt, a hydrate or a solvate.
REFERENCES:
patent: 4539323 (1985-09-01), Mentrup et al.
patent: 6995184 (2006-02-01), Barth et al.
patent: WO 98/43636 (1998-10-01), None
patent: WO 01/64632 (2001-09-01), None
Beringue, V., et. al., Creutzfeldt-Jakob disease: Therapeutic Strategies, Expert Opinion on Investigational Drugs (1997), vol. 6, No. 4, pp. 345-348 ( CA 126:324757).
Brittan, H.G., et. al., Polymorhphism in Pharmaceutical Solids, Pharmaceutical Sciences vol. 95 pp. 5-8, (1999).
Cecil, et. al., Disorders of the Inflammatory Response, Textbook of Medicine (1982), pp. 1397-1401.
Grever, M. R., et. al., The National Cancer Instituted: Cancer Drug Discovery and Development Program, Seminars in Oncology, vol. 19, No. 6 (1992) pp. 622-638.
Heinonen, T.M., et. al., Inhibition of Acyl Coenzyme A-Cholesterol Acyltransferase: A Possible Treatment of Atherosclerosis?, Current Atherosclerosis Reports (2002) vol. 4, No. 1, Summary.
Thomas, D., et. al., Is Regression Possible of Atherosclerosis Possible?, Archives de Maladies du Coeur et des Vaisseaux, (1992), vol. 85, No. III, Summary.
Tomlinson, D.R., et. al., Neurotrophic Factors—Regulation of Neuronal Phenotype, Neuroscience Research Communication (1997) vol. 21, No. 1, pp. 57-66 (CA 127:174580).
Ueda, et al.; “The fatty acid amide hydrolose (FAAH)”; Chemistry and Physics of Lipids (2000), 108, pp. 107-121.
Martin, et al.; “Cannabinoid Transmission and Pain Reception”, Neurobiology of Disease, 1998, 5, pp. 447-461.
Pionnelli, et al.; The Endocannabinoid System as a Target for Therapeutic Drugs; Trends in Pharmacological Sciences 2000, 21, pp. 218-224.
Van Sickle, et al.; “Cannabinoids Inhibit Emesis Through CB1 Receptors in the Brainstorm of the Ferret”; Gastroenterology 2001, 121, pp. 767-774.
Porter, et al; “The Endocannabinoid Nervous System; Unique Opportunities for Therapeutic Intervention”; Pharmacology and Therapetuics 2001, 90, pp. 45-60.
Carley, et al.; “Functional Role for Cannabinoids in Respiratory Stability During Sleep”, Neuropsychopharmacology 2001, 25, pp. S36-S39.
Smith, et al.; “Anandamide Induces Cardiovascular and Respiratory Reflexes via Vasosensory Nerves in the Anasthetized Rat”; British Journal of Pharmacology 2001, 134, pp. 655-663.
Consroe; “Brain Cannabinoid Systems as Targets for the Therapy of Neurological Disorders”; Neurobiology of Disease 1998, 5, pp. 534-551.
Salzet, et al.; “Comparative biology of the Endocannabinoid System”; European Journal of Biochemistry 2000, 267, pp. 4917-4927.
Petrocellis, et al.; “Endocannabinoids and Fatty Acid Amides in Cancer, Inflammation and Related Disorders”; Chemistry and Physics of Lipids 2000, 108, pp. 191-209.
Jaggar, et al.; “The Anti-Hyperalgesic Actions of the Cannabinoid Anandamide and the Putative CB2 Receptor Agonist Palmitoyethanolamide in Visceral and Somatic Inflammatory Pain”; Pain 1998, 76, pp. 189-199.
Alzzo, et al., “The Gastrointestinal Pharmacology of Cannabinoids”; Current Opinion in Pharmcology 2001, 1, pp. 597-603.
Mendelson, et al., “The Hypnotic Actions of the Fatty Acid Amide, Oleamide”; Neuropsychopharmacology 2001, 25, pp. S36-S39.
Abouabdellah Ahmed
Burnier Philippe
Hoornaert Christian
Jeunesse Jean
Puech Frederic
Farquharson-Torres Serena
Jarrell Noble
Leeser Erich A
Sanofi-Aventis
Scully , Scott, Murphy & Presser, P.C.
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