Therapeutic uses of chemokine variants

Drug – bio-affecting and body treating compositions – Lymphokine

Reexamination Certificate

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C424S185100, C424S192100, C424S198100, C514S002600, C530S324000

Reexamination Certificate

active

07740833

ABSTRACT:
Variants of homodimer-forming chemokines, such as human CCL2, having a single amino acid substitution in the dimerization interface that alters the pattern of hydrogen bonds and acting as an obligate monomer, can antagonize natural chemokines and have anti-inflammatory activity in vivo. These variants can be used as active ingredient in pharmaceutical compositions for the treatment of inflammatory, autoimmune, or infectious diseases.

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