Therapeutic uses of BPI protein products in BPI-deficient humans

Details Therapeutic uses of BPI protein products in BPI-deficient humans Therapeutic uses of BPI protein products in BPI-deficient humans

1999-04-01

2000-11-28

Brusca, John S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530350, 530324, 435 691, A61K 3800, C07K 100, C07K 1600, C07K 1700, C12P 2106

Patent

active

061535842

ABSTRACT:
New therapeutic uses for BPI protein products that involve treatment of subjects with a BPI deficiency condition, including selective BPI deficiency, and newborns, particularly BPI-deficient newborns.

REFERENCES:
patent: 5827816 (1998-10-01), Theofan et al.
Wong HR et al, "Plasma bactericidal/permeability-increasing protein concentrations in critically ill children with the sepsis syndrome", Pediatr Infect Dis J., Dec. 1995, vol. 14, Vo. 12, pp. 1087-1091.
Anonymous, "Supplementation and plasma levels of vitamin A in premature newborns at risk for chronic lung disease. Italian Collaborative Group on Preterm Delivery (ICGPD)", Dev Pharm and Therapeutics, 1993 20(3-4), pp. 144-151.
Sands KE et al, "Epidemiology of sepsis syndrome in 8 academic medical centers", JAMA, Jul. 16, 1997 vol. 278, No. 3, pp. 234-240.
McCourt M, "At risk for infection : the very low birthweight infant", J of Perinatal and Neonatal Nursing, Mar. 1994, vol. 7, No. 4, pp. 52-64.
Ammons et al, "An N-terminal fragment of bactericidal/permeability-increasing protein protects against hemodynamic and metabolic derangements in rat gram-negative sepsis", J. Endotoxin Res, 1996, 3(1), pp. 57-66.
Elsbach P et al, "Prospects for use of recombinant BPI in the treatment of gram-negative bacterial infections", Infectious Agents and disease, Jun. 1995, 4(2) ages 102-9.

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