Therapeutic uses for sodium 2-mercaptoethanesulphonate (mesna)

Details Therapeutic uses for sodium 2-mercaptoethanesulphonate (mesna) Therapeutic uses for sodium 2-mercaptoethanesulphonate (mesna)

1995-06-07

1997-08-26

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Sulfur, selenium or tellurium compound

A61K 3110

Patent

active

056611889

ABSTRACT:
Uses for the compound sodium mercaptoethanesulphonate, commonly known as mesna are disclosed. The appropriate periodic administration of said compound to a patient or the addition of the compound to a preservation solution for a donor organ can prevent reperfusion injury. Likewise, the prescribed periodic administration of mesna to a patient whose peritoneum is about to be violated will aid in avoiding peritonitis.

REFERENCES:
patent: 4623742 (1986-11-01), Scheffler et al.
patent: 4929607 (1990-05-01), Scheffler et al.
MEXAN Uroprotector, ASTA Pharma AG, Weismullerstrasse, D-6,000 Frankfort 1 FRG (Dec. 1990).
Drug Evaluation Monographs, MESNA, Micromedex, Inc. vol. 83, Mar. 31, 1995.
"Free Radicals: From Basic Science to Medicine," VI Biennial Meeting, International Society for Free Radical Research, Torino (Italy), Volume of Abstracts, Jun. 16-20, 1992.
Cardio Science, 3(3): 179-887, Sep. 1992. Abstract.
Pharmacol-Res, 25 Suppl 1:85-6, Feb.-Mar. 1992. Abstract.
Ann-Oncol, 3 Suppl 2:S115-8, Apr. 1992. Abstract.

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