Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1997-05-16
2000-11-07
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514178, 514182, A61K 3156
Patent
active
061437387
ABSTRACT:
A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of cancers, such as leukemia; inflammation; arthritis; and viruses, such as HSV. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, inflammation, arthritis, herpes simplex virus, melanoma, and leukemia may be treated by administering an effective amount of the pharmaceutical compositions. Viral replication, weight gain, and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions. Appetite can be suppressed by administering an effective amount of the pharmaceutical compositions, and a diuretic effect can be produced.
REFERENCES:
patent: 3016390 (1962-01-01), Counsell
patent: 3370070 (1968-02-01), Klimstra et al.
patent: 4220598 (1980-09-01), Hixson, Jr. et al.
patent: 4372888 (1983-02-01), Hjelmeland
patent: 4425273 (1984-01-01), Iida et al.
patent: 4514393 (1985-04-01), Castagnola et al.
patent: 4545938 (1985-10-01), Mosbach et al.
patent: 4550163 (1985-10-01), Voss et al.
patent: 4565811 (1986-01-01), Di Schiena
patent: 4771042 (1988-09-01), Braughler et al.
patent: 4793948 (1988-12-01), Hatono et al.
patent: 4966897 (1990-10-01), Angelastro et al.
patent: 4994443 (1991-02-01), Folkman et al.
patent: 5001116 (1991-03-01), Folkman et al.
patent: 5004737 (1991-04-01), Kim et al.
patent: 5039529 (1991-08-01), Bergendal et al.
patent: 5057509 (1991-10-01), Pellicciari et al.
patent: 5061701 (1991-10-01), Pellicciari et al.
patent: 5063222 (1991-11-01), Komoto et al.
patent: 5075464 (1991-12-01), Blohm et al.
patent: 5135919 (1992-08-01), Folkman et al.
patent: 5192756 (1993-03-01), Zasloff et al.
patent: 5250524 (1993-10-01), Kramer et al.
patent: 5637691 (1997-06-01), Frye et al.
patent: 5763430 (1998-06-01), Zasloff
patent: 5840936 (1998-11-01), Zasloff et al.
McKenna, James et al., "Bis-steroids as Potential Enzyme Models: Perylene Solubilisation and Dye Spectral Changes with Aqueous Solutions of Some Derivatives of Conessine and Cholic Acid;" J.C.S. Chem. Comm., 1977, pp. 809-811.
Crum, Rosa et al., "A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment," Science, vol. 230, 1985, pp. 1375-1378.
Derwent Abstract No. 86-085704, "Anticancer Drug Contains Shark Liver Extract Doxorubicin," 1984.
Biosis No. 82085007, "Studies on Antitumor Activity of Squalene and Its Related Compounds," Yakugaku Zasshi, 1986.
Chemical Abstract No. 111: 17264, "Increasing the Therapeutic Efficacy of Antitumor Drugs," 1989.
Bellini, A.M. et al., "Antimicrobial Activity of Basic Cholane Derivatives, Part IX," Arch. Pharm. (Weinheim) 323, 201-205 (1990).
Bellini, Anna M. et al., Antimicrobial Activity of Basic Cholane Derivatives. X. Synthesis of 3.alpha.- and 3.beta.-amino-5.beta.-cholan-24-oic Acids, Steroids, vol. 56, Jul. 1991, pp. 395-397.
Gagliardi, A., et al., "Inhibition of Angiogenesis by Antiestrogens," Cancer Research, 53, pp. 533-535, Feb. 1, 1993.
Moore, Karen S. et al., "Squalamine: An Aminosterol Antibiotic from the Shark," Proc. Natl. Acad. Sci., USA, vol. 90, pp. 1354-1358, Feb. 1993.
Wehrli, S. et al., "Structure of the Novel Steroidal Antibiotic Squalamine Determined by Two-Dimensional NMR Spectroscopy," Steroids, vol. 58, No. 8, Aug. 1993, pp. 370-378.
Children's Hospital of Pennsylvania, "Aminosterol Antibiotic;" Current Opinion in Therapeutic Patents Sep. 1993, pp. 1369-1370.
Auerbach, R. et al., "Angiogenesis Inhibition: A Review;" Pharmac. Ther., vol. 63, pp. 265-311, 1994.
Moriarty, Robert M. et al., "Synthesis of Squalamine, A Steroidal Antibiotic from the Shark," Tetrahedron Letters, vol. 35, No. 44, pp. 8103-8106, 1994.
Sadownik, Andrzej et al., "Rapid Construction of a Squalamine Mimic;" J. Am. Chem. Soc., 1995, vol. 117, pp. 6138-6139.
"Shark Cartilage for Cancer Treatment," P&T Newsletter, Mar. 1996, pp. 159-160.
"Designing Therapies that Target Tumor Blood Vessels;" Science, vol. 275, Jan. 24, 1997, pp. 482-484.
Akhter, "Squalamine, A Novel Aminosterol Antibiotic is a Specific Inhibitor of Epithelial Brush Border Na.sup.+ /H.sup.+ Exchanger Isoform, NHE3," FASEB Journal, vol. 10, No. 3 (1996), p. A89.
Nath, "The Novel Aminosterol Antibiotics Squalamine and 1436 are Specific Inhibitors of Epithelial Brush Border Na.sup.+ /H.sup.+ Exchanger (NHE) Isoform, NHE3," Gastroenterology, vol. 110, No. 4, Suppl. (1996), A349.
Goldberg Jerome D.
Magainin Pharmaceuticals Inc.
LandOfFree
Therapeutic uses for an aminosterol compound does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Therapeutic uses for an aminosterol compound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic uses for an aminosterol compound will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1641253