Therapeutic uses for aminosterol compounds

Details Therapeutic uses for aminosterol compounds Therapeutic uses for aminosterol compounds

2000-07-13

2008-08-12

Padmanabhan, Sreeni (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

C514S187000, C514S179000, C552S521000

Reexamination Certificate

active

07410959

ABSTRACT:
A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG.1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of obesity or diabetes. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, diabetes and obesity may be treated by administering an effective amount of the pharmaceutical compositions. Weight gain, and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions. Appetite can be suppressed by administering an effective amount of the pharmaceutical compositions, and a diuretic effect can be produced.

REFERENCES:
patent: 5763430 (1998-06-01), Zasloff
patent: 5792635 (1998-08-01), Zasloff
patent: 5842740 (1998-12-01), Lefranc
patent: 5847172 (1998-12-01), Zasloff
patent: WO 96/40151 (1966-12-01), None
patent: WO 96/40728 (1996-12-01), None
patent: WO 96/44044 (1997-11-01), None
patent: WO 98/19682 (1998-05-01), None
Beers, M., The Merck Manual of Diagnosis and Therapy (17th ED) (1999), p. 1654-1656.
Zasloff, et al., “A spermine-coupled cholesterol metabolite from the shark with potent appetite suppresment and antidiabetic properties,”International Journal of Obesity. (2002), 25(5), pp. 689-697.
Zasloff, et al., “A centrally acting cholesterol metabolite with potent appetite suppressant and antidiabetic properties,”Pediatrice Research, (Apr. 2002), vol. 47, No. 4, Part 2, p. 142A.

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