Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1994-11-03
1999-07-20
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
514573, A61K 9127, A61K 9133
Patent
active
059253754
ABSTRACT:
This invention provides a multilamellar liposome containing an arachidonic acid metabolite, two or more lipid-containing bilayers and two or more aqueous compartments containing a release-inhibiting buffer. Preferred arachidonic acid metabolites are the prostaglandins, particularly PGE.sub.1. The liposomal formulations can be used to treat animals, particularly humans, for diseases, disorders or conditions which can be ameliorated by prostaglandins, e.g., disorders characterized by cellular activation and adhesion, inflammation and/or toxemia.
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Janoff Andrew S.
Klimchak Robert J.
Lenk Robert P.
Minchey Sharma R.
Ostro Marc J.
Goodman Rosanne
Kishore Gollamudi S.
Rubin Kenneth
The Liposome Company Inc.
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