Therapeutic use of JAK-3 inhibitors

Details Therapeutic use of JAK-3 inhibitors Therapeutic use of JAK-3 inhibitors

1999-07-26

2000-06-27

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31505

Patent

active

060807482

ABSTRACT:
Inhibitors of JAK3 kinase for the treatment of allergy inhibit mast cell degranulation an dmediator release.

REFERENCES:
patent: 4559157 (1985-12-01), Smith et al.
patent: 4608392 (1986-08-01), Jacquet et al.
patent: 4820508 (1989-04-01), Wortzman
patent: 4938949 (1990-07-01), Borch et al.
patent: 4992478 (1991-02-01), Geria
patent: 5817674 (1998-10-01), Clemence et al.
patent: 5916792 (1999-06-01), Civin et al.
Amir, S. et al.,"An inhibitor of nitric oxide production, N.sup.G -nitro-L-arginine-methyl ester, improves survival in anaphylactic shock", Eur. J. Pharmacol., vol. 203, No. 1, pp. 125-127 (Oct. 2, 1991).
Apgar, J., "Increased degranulation and phospholipase A.sub.2, C, and D activity in RBL cells stimulated through Fc.epsilon.R1 is due to spreading and not simply adhesion", J. Cell. Sci., vol. 110, No. 6, pp. 771-780 (Mar. 1997).
Blank, U. et al., "Complete structure and expression in transfected cells of high affinity IgE receptor", Nature, vol. 337, No. 6203, pp. 187-189 (Jan. 12, 1989).
Bohm, H-J, "The development of a simple empirical scoring function to estimate the binding constant for a protein-ligand complex of known three-dimensional structure", J. Comput. Aided Mol. Des., vol. 8, No. 3, pp. 243-256 (Jun. 1994).
Buckley, R. et al., "Human severe combined immunodificiency: Genetic, phenotypic, and functional diversity in one hundred eight infants", J. Pediatr., vol. 130, No. 3, pp. 378-387 (Mar. 1997).
Chen, C-L., et al., "Pharmacokinetics and Biologic Activity of the Novel Mast Cell Inhibitor, 4-(3'-Hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in Mice", Pharmaceutical Research, vol. 16, No. 1, pp. 117-122 (Jan. 1999).
Costello, P. et al., "Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells", Oncogene, vol. 13, No. 12, pp. 2595-2605 (Dec. 19, 1996).
Danial, N. et al., "Jak-STAT Signaling Induced by the v-able Oncogene", Science, vol. 269, No. 5232, pp. 1875-1877 (Sep. 29, 1995).
Darnell, Jr. J. et al., "Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins", Science, vol. 264, pp. 1415-1421 (Jun. 3, 1994).
Deckert, M. et al., "Coordinated Regulation of the Tyrosine Phosphorylation of Cbl by Fyn and Syk Tyrosine Kinases", J. Biol. Chem., vol. 273, No. 15, pp. 8867-8874 (Apr. 10, 1998).
Dvorak, A. et al., "Effects of Interleukin-3 With or Without the c-kit Ligand, Stem Cell Factor, on the Survival and Cytoplasmic Granule Formation of Mouse Basophils and Mast Cells in Vitro", Am. J. Pathol., vol. 144, No. 1, pp. 160-170 (Jan. 1994).
Endo, T. et al., "A new protein containing an SH2 domain that inhibits JAK kinases", Nature, vol. 387, pp. 921-924 (Jun. 26, 1997).
Fusaki, N. et al., "Interaction between Sam68 and Src Family Tyrosine Kinases, Fyn and Lck, in T Cell Receptor Signaling", J. Biol. Chem., vol. 272, No. 10, pp. 6214-6219 (Mar. 7, 1997).
Galli, S., "Seminars in Medicine of the Beth Israel Hospital, Boston: New Concepts About the Mast Cell", New Eng. J. Med., vol. 328, No. 4, pp. 257-265 (Jan. 28, 1993).
Ghosh, S. et al., ".alpha.-Cyano-.beta.-hydorxy-.beta.-methyl-N-[4-(trifluoromethoxy)phenyl] Propenamide: An Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase with Potent Cytotoxic Activity against Breast Cancer Cells", Clin. Cancer Res., vol. 4, No. 11, pp. 2657-2668 (Nov. 1998).
Goodman, P. et al., "Role of Tyrosine Kinases in Induction of the c-jun Proto-oncogene in Irradiated B-Lineage Lymphoid Cells", J. Biol. Chem., vol. 273, No. 28, pp. 17742-17748 (Jul. 10, 1998).
Gordon, J. et al., "Mast cells as a source of both preformed and immunologically inducible TNF-.alpha./cachetin", Nature, vol. 346, No. 6281, pp. 274-276 (Jul. 19, 1990).
Gurniak, C. et al., "Murine JAK3 Is Preferentially Expressed in Hematopoietic Tissues and Lymphocyte Precursor Cells", Blood, vol. 87, No. 8, pp. 3151-3160 (Apr. 15, 1996).
Hamawy, M. et al., "Protein tyrosine phosphorylation as a mechanism of signalling in mast cells and basophils", Cellular Signalling, vol. 7, No. 6, pp. 535-544 (Aug. 1995).
Hanissian, S. et al., "Jak3 Is Associated with CD40 and Is Critical for CD40 Induction of Gene Expression in B Cells", Immunity, vol. 6, No. 4, pp. 379-387 (Apr. 1997).
Hirasawa, N. et al., "A Requirement for Syk in the Activation of the Microtubule-associated Protein Kinase/Phospholipase A.sub.2 Pathway by Fc.epsilon.R1 Is Not Shared by a G Protein-coupled Receptor", J. Biol. Chem., vol. 270, No. 18, pp. 10960-10967 (May 5, 1995).
Hoffman, S. et al., "JAK3 Maps to Human Chromosome 19p12 within a Cluster of Proto-oncogenes and Transcription Factors", Genomics, vol. 43, No. 1, pp. 109-111 (Jul. 1, 1997).
Hogan, A. et al., "Markers of Mast Cell Degranulation", Methods: A Companion to Methods in Enzymology, vol. 13, No. 1, pp. 43-52 (Sep. 1997).
Hubbard, S. et al., "Crystal structure of the tyrosine kinase domain of the human insulin receptor", Nature, vol. 372, No. 6508, pp. 746-754 (Dec. 1994).
Hubbard, S., "Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog", The EMBO Journal, vol. 16, No. 18, pp. 5572-5581 (Sep. 15, 1997).
Ihle, J. et al., "Jaks and Stats in signaling by the cytokine receptor superfamily", Trends in Genetics, vol. 11, No. 2, pp. 69-74 (Feb. 1995).
Ihle, J., "Janus kinases in cytokine signalling", Phil. Trans. R. Soc. Lond. B, vol. 351, No. 1336, pp. 159-166 (Feb. 29, 1996).
Irani, A. et al., "Detection of MC.sub.T and MC.sub.TC Types of Human Mast Cells by Immunohistochemistry Using New Monoclonal Anti-tryptase and Anti-chymase Antibodies", J. Histochem. Cytochem., vol. 37, No. 7, pp. 1509-1515 (1989).
Johnston, J. et al., "Phosphorylation and activation of the JAK-3 Janus Kinase in response to interleukin-2", Nature, vol. 370, No. 6485, pp. 151-153 (Jul. 14, 1994).
Johnston, J. et al., Interleukins 2, 4, 7, and 15 Stimulate Tyrosine Phosphorylation of Insulin Receptor Substrates and 1 and 2 in T Cells, J. Biol. Chem., vol. 270, No. 48, pp. 28527-28530 (Dec. 1, 1995).
Kumar, A. et al., "Structural organization and chromosomal mapping of JAK3 locus", Oncogene, vol. 13, No. 9, pp. 2009-2014 (Nov. 7, 1996).
Lavens-Phillips, S. et al., "The effect of tyrosine kinase inhibitors on IgE-mediated histamine release from human lung mast cells and basophils", Inflamm. Res., vol. 47, No. 3, pp. 137-143 (Mar. 1998).
Leonard, W., "STATs and cytokine specificity. Several STATs transduce signals and activate genes only in response to select cytokines--will all STATs prove so specific?", Nature Medicine, vol. 2, No. 9, pp. 968-969 (Sep. 1996).
Levy, D., "The House that JAK/STAT Built", Cytokine & Growth Factor Reviews, vol. 8, No. 1, pp. 81-90 (Mar. 1997).
Liu, F. et al., "Monoclonal Dinitrophenyl-specific Murine IgE Antibody: Preparation, Isolation, and Characterization", J. Immunol., vol. 124, No. 6, pp. 2728-2737 (Jun. 1980).
Mahajan, S. et al., "Src Family Protein Tyrosine Kinases Induce Autoactivation of Bruton's Tyrosine Kinase", Mol. Cell. Biol., vol. 15, No. 10, pp. 5304-5311 (Oct. 1995).
Mahajan, S. et al., "Rational Design and Synthesis of a Novel Anti-leukemic Agent Targeting Bruton's Tyrosine Kinase (BTK), LFM-A13[.alpha.-Cyano-.beta.-Hydroxy-.beta.-Methyl-N-(2,5-Dibromophenyl)Pr openamide]", J. Biol. Chem., vol. 274, No. 14, pp. 9587-9599 (Apr. 2, 1999).
Malaviya, R. et al., "Reversible Translocation of 5-Lipoxygenase in Mast Cells upon IgE/Antigen Stimulation", J. Biol. Chem., vol. 268, No. 7, pp. 4939-4944 (Mar. 5, 1993).
Malaviya, R. et al., "Mast Cell Phagocytosis of FimH-Expressing Enterobacteria", J. Immunol., vol. 152, 1907-1914 (1994).
Malaviya, R. et al., "Mast Cell Degranulation Induced by Type 1 Fimbriated Escherichia coli in Mice", J. Clin. Invest., vol. 93, pp. 1645-1653 (Apr. 1994).
Malaviya, R. et al., "Histamine in Human Epidermal Cells is Induced by Ultraviolet Light Injury", J. Invest. Dermatol., vol. 106, No. 4, pp. 785-789 (Apr. 1996).
Malaviya, R. et al., "Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through

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