Therapeutic use of hypervariable region of monoclonal antibody M

Details Therapeutic use of hypervariable region of monoclonal antibody M Therapeutic use of hypervariable region of monoclonal antibody M

1995-02-02

1998-03-24

Feisee, Lila

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

4241831, 53038822, 5303913, 5303915, 5303917, 5303919, A61K 39395, C07K 1628

Patent

active

057309825

ABSTRACT:
Therapeutic agents and methods for treating and diagnosing acute or chronic leukemia are provided. Such agents comprises monoclonal antibody M195, or a chimeric antibody containing the hypervariable region of M195, conjugated to a cytotoxic agent, e.g. a radioisotope.

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Blakey et al., "Monoclonal Antibody Therapy Prog Allergy", H. Waldmann Ed., Basel Karger 1988, vol. 45. pp. 50-90.
Engleman et al., Eds. "Human Hybridomas and Monoclonal Antibodies", Plenum Press, 1985, pp. 160-161.

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