Therapeutic use of growth factor, and delivery device,...

Details Therapeutic use of growth factor, and delivery device,... Therapeutic use of growth factor, and delivery device,...

2008-01-22

2008-01-22

Schnizer, Richard (Department: 1635)

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

C604S095030, C604S264000

Reexamination Certificate

active

10370291

ABSTRACT:
The present invention concerns vascular endothelial growth factor (VEGF) which has utility in the treatment of intimal hyperplasia, hypertension and atherosclerosis, and of conditions susceptible to treatment with agents that produce nitric oxide or prostacyclin. Instead of VEGF, an equivalent agent such as an agonist of VEGF receptors may be given, as may nucleic acid encoding such an agonist. The agent may successfully be administered via the adventitial surface of a blood vessel, e.g., using a device which defines a reservoir between the body wall and the vessel's adventitial surface, the reservoir being at least part-filled by a pharmaceutical formulation containing the agent to be delivered.

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