Therapeutic use of growth factor, and delivery device,...

Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C604S095030, C604S264000

Reexamination Certificate

active

07320679

ABSTRACT:
The present invention concerns vascular endothelial growth factor (VEGF) which has utility in the treatment of intimal hyperplasia, hypertension and atherosclerosis, and of conditions susceptible to treatment with agents that produce nitric oxide or prostacyclin. Instead of VEGF, an equivalent agent such as an agonist of VEGF receptors may be given, as may nucleic acid encoding such an agonist. The agent may successfully be administered via the adventitial surface of a blood vessel, e.g., using a device which defines a reservoir between the body wall and the vessel's adventitial surface, the reservoir being at least part-filled by a pharmaceutical formulation containing the agent to be delivered.

REFERENCES:
patent: 3797485 (1974-03-01), Urquhart
patent: 5201728 (1993-04-01), Giampapa
patent: 5326568 (1994-07-01), Giampapa
patent: 5830879 (1998-11-01), Isner
patent: WO94/23668 (1994-10-01), None
patent: WO94/28721 (1994-12-01), None
patent: WO96/33673 (1996-10-01), None
Joukov et al (J. Biol. Chem 273(12): 6599-6602, Mar. 1998).
Olofsson et al (Proc. Nat. Acad. Sci. USA 93: 2576-2581, Mar. 1996).
Laitinen et al (Circulation, (Oct. 15, 1996) vol.94, No. 8, Supp. S, pp. 3720).
Zhang et al (J. Nat. Cancer Inst. 87(3): 213-219, 1995).
Mitola et al (Blood, (Aug. 15, 1997) vol. 90, No. 4, pp. 1365-1372.
Asahara, T. et al., “Local Delivery of Vascular Endothelial Growth Factor Accelerates Reendothelialization and Attenuates Intimal Hyperplasia in Balloon-Injured Rat Carotid Artery,”Circulation1995, vol. 91, No. 11, pp. 2793-2801.
Booth, R.F.G. et al., “Rapid Development of Atherosclerotic Lesions in the Rabbit Carotid Artery Induced by Perivascular Manipulation,”Atherosclerosis1989, vol. 76, No. 2,3, pp. 257-268.
Forte, P. et al., “Basal Nitric Oxide Synthesis in Essential Hypertension,”The Lancet1997, vol. 349, pp. 837-842.
Houck, K.A. et al., “The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA,”Molecular Endocrinology1991, vol. 5, No. 12, pp. 1806-1814.
Laitinen, M. et al., “VEGF Gene Transfer Reduces Intimal Thickening Via Increased Production of Nitric Oxide in Carotid Arteries,”Human Gene Therapy1997, vol. 8, No. 15, pp. 1737-1744.
Laitinen, M. et al., “Local Adventitial VEGF Gene Transfer Reduces Neointima Formation in Rabbit Carotid Arteries,”Circulation1996, vol. 94, No. 8, p. 3720.
Morbidelli, L. et al., “Nitric Oxide Mediates Mitogenic Effect on VEGF on Coronary Venular Endothelium,”American Journal of Physiology1996, vol. 270, No. 1, pp. H411-H415.
Von Der Leyen, H.E. et al., “Gene Therapy Inhibiting Neointimal Lesion: In Vivo Transfer of Endothelial Cell Nitric Oxide Synthase Gene,” Proceedings of the National Academy of Sciences of USA, 1995, vol. 92, pp. 1137-1141.
Zachary, I. et al., “Vascular Endothelial Growth Factor Stimulates Nitric Oxide Production and Prostacyclin Synthesis in Human Umbilical Vein Endothelial Cells,”European Heart Journal1997, vol. 18, abstract. No. 148.
European Search Report for Application No. EP 04 02 1613, Dec. 22, 2004.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Therapeutic use of growth factor, and delivery device,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutic use of growth factor, and delivery device,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutic use of growth factor, and delivery device,... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2788870

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.