Therapeutic use of clostridium difficile toxin A

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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530327, 530409, 530825, C07K 708, C07K 14195, A61K 3810, A61K 3908

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active

054666724

ABSTRACT:
Methods for treating cancer are described, including methods for treating colon and pancreatic cancer. Bacterial toxins and portions of bacterial toxins are employed as both diagnostic and therapeutic agents.

REFERENCES:
patent: 4650674 (1987-03-01), Aggarwal et al.
patent: 4894443 (1990-01-01), Greenfield et al.
patent: 4962188 (1990-10-01), Frankel
patent: 5087616 (1992-02-01), Myers et al.
S. Donta et al., "Differential Effects of Clostridium difficile Toxins on Tissue-Cultured Cells," J. Clin. Microbiol. 15:1157 (1982).
C. Fiorentini et al., "Effects of Clostridium Difficile Toxins A and B on Cytoskeleton Organization in HEp-2 Cells: A Comparative Morphological Study," Toxicon 27:1209 (1991).
H. Krivan and T. Wilkins "Purification of Clostridium difficle Toxin A by Affinity Chromatography on Immobilized Thyroglobulin," Infect. Immun. 55:1873 (1987).
V. M. Kushnaryov et al., "Reversibility of Action of Clostridium Difficile Toxin A on Cho Cells and Intermediate Filaments in Nuclei," Proc. 46th Ann. Meeting Electron Microscopy Soc. Amer., 1988, p. 134.
A. Lima et al, "Clostridium Difficile Toxin A Interactions with Mucus and Early Sequential Histopathologic Effects in Rabbit Small Intestine," Laboratory Investigation 61:419 (1989).
A. Lima et al., "Effects of Clostridium difficile Toxins A and B in Rabbit Small and Large Intestine in Vivo and on Cultured Cells in Vitro," Infect. Immun. 56:582 (1988).
S. W. Rothman et al., "Differential Cytotoxic Effects of Toxins A and B Isolated from Clostridium difficile", Infect. Immun. 46:324 (1984).
J. Torres et al., "Sensitivity in Culture of Epithelial Cells from Rhesus Monkey Kidney and Human Colon Carcinoma to Toxins A and B from Clostridium Difficile," Toxicon 30:419 (1992).
Boring et al., Cancer Statistics, Cancer J. Clin. 42:19 (1992).
Macdonald et al., "5-Fluorouracil, Adriamycin, and Mitomycin-C (FAM) Combination Chemotherapy in the Treatment of Advanced Gastric Cancer," Cancer 44:42 (1979).
Gerlach et al., "Multidrug Resistance," Cancer Surv. 5:25 (1986).
Goldie and Coldman, "The Genetic Origin of Drug Resistance in Neoplasms: Implications for Systemic Therapy," Cancer Res. 44:3643 (1984).
Gottesman and Pastan, "Resistance to Multiple Chemotherapeutic Agents in Human Cancer Cells," Trends Pharm. Sci. 9:54 (1988).
Fischerman et al., "Survival among patients with Liver Mestastases from Cancer of the Colon and Rectum," Scand. J. Gastroent. Suppl. 37:111 (1976).
Anai et al., "Sensitivity Test for 5-Fluorouracil and Its Analogues, 1-(2-Tetrahydrofuryl)-5-Fluorouracil, Uracil/1-(2-Tetrahydrofuryl)-5-Fluorouracil (4:1) and 1-Hexylcarbamoyl-5-Fluoroacil, Using the Subrenal Capsule Assay," Oncology 45:144 (1988).
Lyerly et al., "Clostridium difficile: Its Disease and Toxins," Clin. Microbiol. Rev. 1:1 (1988).
Dove et al., "Molecular Characterization of the Clostridium difficile Toxin A Gene," Infect. Immun. 58:480 (1990).
Fiorentini and Thelestam, "Clostridium Difficile Toxin A and its Effects on Cells," Toxicon 29:543 (1991).
Kushnaryov and Sedmak, "Effect of Clostridium difficile Enterotoxin A on Ultrastructure of Chinese Hamster Ovary Cells," Infect. Immun. 57:3914 (1989).
Kushnaryov et al., "Actin and Iamin Comprised Filaments in the Nuclei of Chinese Hamster Ovary Cells Affected with Clostridium difficile Enterotoxin A," Cytobios 64:181 (1990).
Fiorentini et al., "Interaction of Clostridium difficile Toxin A with Cultured Cells: Cytoskeletal Changes and Nuclear Polarization," Infect. Immun. 58:2329 (1990).
Kushnaryov et al., "Cytotoxicity of Clostridium difficile Toxin A for Human Colonic and Pancreatic Carcinoma Cell Lines .sup.1," Cancer Res. 52:5096 (1992).
Redlich et al., "Selective Cytotoxicity of Clostridium difficile Enterotoxin A for Cancer Cell Lines of Gastrointestinal Tract Origin," Proc. Am. Assoc. Cancer Res. (1992).
Wren et al., "Antigenic Cross-Reactivity and Functional Inhibition by Antibodies to Clostridium difficile Toxin A, Streptococcus Mutans Glucan-Binding Protein, and a Synthetic Peptide," Infect. Immun. 59:3151 (1991).
V. Kushnaryov et al., "Cytotoxicity of Clostridium Difficile Entertoxin A: Unusual Intranuclear Structures in Cho Cells," Abstracts, P13.3.12, Fourth International Congress of Cell Biology, Montreal, Quebec, Canada, Aug. 14-19, 1988.
V. Ling, "P-Glycoprotein-Mediated Multidrug Resistance to Cancer Chemotherapy," Advances in Oncol. 9:3 (1993).
N. Sullivan et al., "Purification and Characterization of Toxins A and B of Clostridium difficile," Infect. Immun. 35:1032 (1982).
S. Donta and S. Shaffer, "Effects of Clostridium difficile Toxin on Tissue-Cultured Cells," J. Infect. Diseases 141:218 (1980).

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