Therapeutic use of bFGF to treat conditions involving adhesion o

Details Therapeutic use of bFGF to treat conditions involving adhesion o Therapeutic use of bFGF to treat conditions involving adhesion o

1997-08-29

2000-01-04

Azpuru, Carlos A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

A61F 202

Patent

active

06010712&

ABSTRACT:
A method of treating a condition involving vascular adhesion of cytotoxic white cells by (a) identifying an animal suspected of having a condition involving vascular adhesion of cytotoxic white cells and (b) administering to the animal an amount of bFGF sufficient to decrease cell surface expression of ICAM-I or VCAM-I on endothelial cells, thereby reducing adhesion of cytotoxic white cells to vascular endothelium.

REFERENCES:
Melder et al., During Angiogenesis, Vascular endothelium Growth factor and Basic Fibroblast Growth factor regulate Natural Killer Cell Adhesion to Tumour Endothelium Abstract only, Nat. Med. (NY) 2(9), 992-997, 1996.
Kitayama et al., Suppressive Effect of Basic Fibroblast Growth Factor on Transendothelial Emigration of CD4(.times.) T-Lymphocyte, Abstract only, Cancer Reseach, 54(17), 4729-33, 1994.
Griffioen et al., "Endothelial Intercellular Adhesion Molecule-1 Expression Is Suppressed in Human Malignancies: The Role of Angiogenic Factors", Cancer Research 56:1111-1117, Mar. 1, 1996.
Griffioen et al., "Tumor Angiogenesis Is Accompanied by a Decreased Inflammatory Response of Tumor-Associated Endothelium", Blood 88:667-673, Jul. 15, 1996.
Jain et al., "Leukocyte-endothelial Adhesion and Angiogenesis in Tumors", Cancer and Metastasis Reviews 15:195-204, 1996.

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